background recurrent pregnancy loss (rpl) is a serious problem for pregnancy. there is evidence that vascular complications play a principal role in rpl. methylenetetrahydrofolate reductase (mthfr) is a key enzyme in folate metabolism. polymorphisms (c677t, a1298c) of mthfr gene are associated with decreased mthfr activity. objectives the aim of this study was to determine the association betwe...

Abstract Extracellular matrix (ECM) is characterized as widespread, abundant, and pluripotent. Among ECM members, collagen widely accepted one of the most prominent components for its essential structural property that can provide a scaffold other rich biological functions, which has been extensively used in tissue engineering. Emerging evidence shown balance degradation remodeling vital to reg...

Research question: Do miRNAs play a role in regulating endoplasmic Reticulum Stress (RS) and Unfolded Protein Response (UPR) decidualized cells endometrium associated with reproductive failures?Design: Endometrial stromal cell line St-T1b was vitro 8-Br-cAMP during 5 days, or treated the RS-inducer Thapsigargin (Tg). Expression of RS-sensors, UPR markers potential miRNA regulators were analysed...

  Background: Open Bankart surgery is the main treatment procedure in patients with recurrent anterior shoulder dislocation, especially in cases with glenoid bone defect. The goal of this study was to determine the outcomes after open Bankart surgery in cases of recurrent anterior shoulder dislocation with glenoid bone defects and concomitant Hill-Sachs lesions. Methods: Between 2006 and 2010,...

Objective: Recurrent pregnancy loss is a global issue. This study was planned in order to evaluate the effects of high dose intravenous immunoglobulin (IV Ig) in primary and secondary unexplained miscarriages in patients of recurrent pregnancy loss. Patients and Methods: Total 168 couples having history of primary or secondary recurrent pregnancy loss were included in the study. They were divid...

Vascular endothelial growth factor (VEGF) regulates endothelial cell proliferation, migration and differentiation. VEGF plays a critical role in angiogenesis during placenta formation. We investigated whether VEGF gene polymorphisms are associated with recurrent pregnancy loss. Thirty-eight women with recurrent pregnancy loss and 30 control women with live-born children were recruited from 2010...

background:   objective: to investigate the effectiveness of levothyroxine in treatment of rpl in women with high auto-thyroid antibodies.   materials and methods: in this observational cross sectional study, 900 women who had a history of recurrent pregnancy loss were studied. all women with high anti-tpo antibody without any other problems entered in this study. levothyroxine was given to the...

Background Platelets contain a significant amount of growth factors that have positive effects on local tissue repair and endometrial receptivity. Case Here we present a 45-yr-old woman with primary infertility and two failed in vitro fertilization (IVF) cycles who was candidate to receive donor eggs. Five consecutive frozen-thawed embryo transfer cycles with good quality embryos were perform...