Delayed rectifier potassium current diversity and regulation are essential for signal processing and integration in neuronal circuits. Here, we investigated a neuronal role for MinK-related peptides (MiRPs), membrane-spanning modulatory subunits that generate phenotypic diversity in cardiac potassium channels. Native coimmunoprecipitation from rat brain membranes identified two novel potassium ...

This paper presents optimized fuzzy variable structure control design in a three phase rectifier to correct the power factor. This control strategy combines fuzzy and sliding mode control algorithms. Few fuzzy rules are used for this scheme. The parameters of the fuzzy controller are adjusted by using the VSC for a better response and robustness. To improve the behavior of the system is applied...

Due to the intensified BLDC motor applications in recent decades, Power factor correction (PFC) converters have attracted several researchers. In previous research works, SEPIC converter with the Tapped Inductor model operating in Discontinuous Conduction Mode (TI-SEPIC-DCM) to produce significant results. This work proposes a novel idea of bridgeless rectifier for PFC to enhance rectifier powe...

New bridgeless single-phase ac–dc power factor correction (PFC) rectifier based on Sepic topology is proposed. The absence of an input diode bridge and the presence of only two semiconductor switches in the current flowing path during each switching cycle result in less conduction losses and improved thermal management compared to the conventional Sepic PFC converter. The proposed topology is d...

Rectifying neurons are more biologically plausible than sigmoid neurons, which are more biologically plausible than hyperbolic tangent neurons (which work better for training multi-layer neural networks than sigmoid neurons). We show that networks of rectifying neurons yield generally better performance than sigmoid or tanh networks while creating highly sparse representations with true zeros, ...

Methods from convex optimization are widely used as building blocks for deep learning algorithms. However, the reasons for their empirical success are unclear, since modern convolutional networks (convnets), incorporating rectifier units and max-pooling, are neither smooth nor convex. Standard guarantees therefore do not apply. This paper provides the first convergence rates for gradient descen...

Nonsedating H1 receptor (H1-R) antagonists exert variable effects on QT interval, most likely mediated through modulation of cardiac K+ channels. We examined the effects of a novel H1-R antagonist, ebastine, on a family of K+ currents in isolated rat and guinea pig ventricular cardiomyocytes as well as on HERG-induced rapidly delayed rectifier K+ current (I(Kr)) in Xenopus laevis oocytes. The e...

This paper aims to design a PID compensator for the control of Synchronous Rectifier (SR) Buck Converter to improve its conversion efficiency under different load conditions. Since the diode rectifier is replaced by a high frequency MOSFET switch, the SR control method itself will be sufficient under heavy load condition, to attain better normal mode performance. However, this technique does no...

We have identified a series of diphenyl phosphine oxide (DPO) compounds that are potent frequency-dependent inhibitors of cloned human Kv1.5 (hKv1.5) channels. DPO inhibited hKv1.5 expressed in Chinese hamster ovary cells in a concentration-dependent manner preferentially during channel activation and slowed the deactivating tail current, consistent with a predominant open-channel blocking mech...