Topical foscarnet (PFA) and acyclovir (ACV) were compared in the dorsal cutaneous guinea pig model of herpes simplex virus type 1 infection. The relative order of efficacy was PFA cream greater than ACV cream greater than ACV ointment. In vitro studies demonstrated that PFA and ACV formulated in cream vehicles penetrated through guinea pig skin 7- to 10-fold faster than did ACV in ointment.

Extracts of Aloe vera whole plant, Eucalyptus globulus leaves, Ficus infectoria bark, Ficus religiosa bark and Piper betel leaves were studied for antibacterial activity on resistant and sensitive strains, isolated from skin and soft tissue infections. A combination of hot alcoholic extracts of Ficus infectoria, Ficus religiosa and Piper betel were found to be more effective against all the iso...

Shark (Carcharhinus sorrah) is a fish whose entire endoskeleton composed of cartilage. Fish cartilage widely used for treatment because shark (SC) contains glucosamine (GS) and chondroitin sulfate (CS) compounds. This study aims to determine the benefits derived from SC extract on lizard tail regeneration. The was initiated by testing characteristics ointment which included tests spreadability,...

BACKGROUND The chronic and relapsing nature of vulvar lichen sclerosus (VLS) represents a challenge for its long-term management after an effective treatment with topical corticosteroids. OBJECTIVES To assess the effectiveness of proactive, twice-weekly application of mometasone furoate 0·1% ointment, compared with daily topical vitamin E or cold cream, in keeping VLS in remission and reducin...

BACKGROUND Psoriasis is a chronic inflammatory skin disease with a major impact on the quality of life of affected individuals. Topical therapy has an important role in the treatment of psoriasis. Poor treatment outcomes from topical therapy regimens likely result from poor adherence and ineffective use of medication. METHODS A cost-minimization analysis was performed with the purpose of asse...

Objectives: The purpose of this work was development, formulation and testing of new herbal ointment for the treatment of mild to severe atopic dermatitis in infants and children (4 to 56 months old) as possible alternative therapy to standard corticosteroids and immunomodulants. Patients and methods: 50 patients were treated 8 weeks (every four hours) with the ointment containing the following...

Pneumonia due to serotypes D-K of Chlamydia trachomatis occurred in a 10-week-old baby, who had been successfully treated with chlortetracycline eye ointment for chlamydial ophthalmia neonatorum, and in a 7-week-old baby being treated for the same condition. Clinical signs of pneumonia were minimal. Such chlamydial pneumonia in infants must be under-diagnosed. Infants with chlamydial ophthalmia...

A sulphydryl plant protease present in the latex of Ficus hispida Linn affects hatematological values in mice. The isolated protease was found to increase clotting time and erythrocyte sedimentation rate while haemoglobin conten, RBC count and WBC count were decreased in a dose dependent manner. Ointment containing 1.0% (w/w) hispidain in washable ointment base showed good wound healing propert...