Epilepsy is a chronic disease affects CNS in various ages. WHO estimates 50 million people are suffering from epilepsy worldwide which make it a serious prevalent problem among neurological diseases. Intractable epilepsy (IE) affects about 20-30% of epileptic patients who failed to be seizure - free after antiepileptic drug (AED) consumption. Although many AEDs now are available for epilepsy tr...

Department of Building and Industrial Production Engineering, University CEU Cardenal Herrera Avda.Seminario s/n, 46113, Moncada, Valencia, Spain Email: [email protected], [email protected], [email protected], [email protected] (*corresponding author), web page: http://www.uchceu.es Departamento de Ingeniería Mecánica y de Materiales, Universidad Politécnica de Vale...

The presence of maternal autoantibodies has been previously associated with preeclampsia, although the composition of the antibody repertoire in preeclampsia has not been well characterized. Given this, we applied a bacterial display peptide library to identify peptides that preferentially react with plasma antibodies from patients with preeclampsia (n=15) versus healthy-outcome pregnancies (n=...

The neuropeptide CGRP can influence the outcome of in vitro antigen presentation through actions on ECs acting as bystanders. To examine this pathway vivo, we used an inducible, conditional knockout (KO) mouse with RAMP1 (part receptor) deleted ECs. Upon skin immunization dinitrofluorobenzene (DNFB), stimulated CD4+ T cells from draining lymph nodes (LNs) had significantly reduced IL-17A expres...

Neurofibromatosis type 2 (NF2), earlier known as bilateral acoustic neurofibromatosis, is an autosomal dominant disorder considered by the development of multiple tumours. It caused mutations in NF2 gene present at long arm chromosome number 22 (22q12.2) which encodes for merlin protein (tumour suppressor gene), found schwann cells involved interaction cell with extracellular matrix after bindi...

Abstract Extracellular signaling molecules, among them the fibroblast growth factors (FGFs), enable cells to communicate with neighboring cells. Such molecules that receive and transmit a signal require specific tyrosine kinase receptors located at cell surface (fibroblast factor receptors, FGFRs). The binding of molecule its receptor results in dimerization conformational changes cytoplasmic p...

To study possible functional differences of the 18-kD and high molecular weight forms of basic fibroblast growth factor (bFGF), we have examined the effect of endogenous production of different bFGF forms on the phenotype of NIH 3T3 cells. Cells transfected with cDNAs coding for either 18-kD bFGF (18-kD bFGF) or all four molecular forms (18, 22, 22.5, 24 kD; wild type [WT] bFGF) exhibit increas...