In 7 open-chest anesthetized mongrel dogs the left anterior descending coronary artery was occluded for 20 sec. Myocardial reactive hyperemia was recorded during air and oxygen breathings. The excess blood flow during the reactive hyperemia was smaller and the duration of the reactive hyperemia was shorter during oxygen breathing than during air breathing. It is suggested that the reduction of ...

Reactive oxygen species comprise oxygen-based free radicals and non-radical such as peroxynitrite electronically excited (singlet) oxygen. These reactive often have short lifetimes, much of our understanding their formation reactivity in biological especially medical environments has come from complimentary fast reaction methods involving pulsed lasers high-energy radiation techniques. related ...

glycation is a protein modification, which results in a change in a protein structure. glycation is believed to be the etiology of various age-related diseases such as diabetes mellitus and alz-heimer’s disease (ad). activation of microglia and resident macrophages in the brain by glycated proteins with subsequent oxidative stress and cytokine release may be an important factor in the progressi...

Faraci, Frank M. Reactive oxygen species: influence on cerebral vascular tone. J Appl Physiol 100: 739–743, 2006; doi:10.1152/japplphysiol.01044.2005.—Reactive oxygen species have multiple effects on vascular cells. Defining the sources and the impact of the various reactive oxygen species within the vessel wall has emerged as a major area of study in vascular biology. This review will focus on...