A rapid compression machine (RCM) has been designed and built for investigating the autoignition characteristics of bio-derived jet and diesel fuels. The RCM has been designed with a particular emphasis on versatility, so that non-volatile fuels may be tested in a premixed gas phase, as a fuel spray, or as an aerosol in an oxidizing bath gas. A blend of these test approaches provides insight in...

A silver-free methodology was developed for the synthesis of unprecedented N-heterocyclic carbene ruthenium indenylidene complexes bearing a bidentate picolinate ligand. The highly stable (SIPr)(picolinate)RuCl(indenylidene) complex 4a (SIPr = 1,3-bis(2-6-diisopropylphenyl)imidazolidin-2-ylidene) demonstrated excellent latent behaviour in ring closing metathesis (RCM) reaction and could be acti...

In the past two decades, alkene metathesis has risen in prominence to become a significant synthetic strategy for alkene formation. Many total syntheses of natural products have used this transformation. We review the use, from 2003 to 2015, of ring-closing alkene metathesis (RCM) for the generation of dihydrofurans or -pyrans in natural product synthesis. The strategies used to assemble the RC...

Benefits In the past, preventive maintenance was performed without any guidance or regard for safety or cost concerns, as long as systems performed their functions. The primary reason for the development of RCM was to implement a preventive maintenance strategy that could adequately address system availability and safety at the lowest possible cost. The RCM process answers and directs preventiv...

Detecting pedestrians is a challenging problem owing to the motion of the subjects, the camera and the background and to variations in pose, appearance, clothing, illumination and background clutter. The Region Covariance Matrix (RCM) descriptors show experimentally significantly out-performs existing feature sets for pedestrian detection. In this paper, we present an efficient features extract...

Peptidomimetic inhibitors of the hepatitis C NS3 protease often exhibit poor biopharmaceutical properties. Structure modification of a substrate-based tripeptide into a b-strand 15-membered ring scaffold provided a new class of peptidomimetics that are significantly superior as drug candidates to their acyclic precursors. Tripeptide dienes composed of three unnatural amino acid residues with nu...

Bicyclic peptides are promising scaffolds for the development of inhibitors of biological targets that proved intractable by typical small molecules. So far, access to bioactive bicyclic peptide architectures is limited due to a lack of appropriate orthogonal ring-closing reactions. Here, we report chemically orthogonal ring-closing olefin (RCM) and alkyne metathesis (RCAM), which enable an eff...

Traditional maintenance planning is based on a constant maintenance interval for equipment life. In order to consider economic aspect for time based preventive maintenance, preventive maintenance is desirable to be scheduled by RCM(ReliabilityCentered Maintenance) evaluation. So, Markov state model is utilized considering a stochastic state in RCM. In this paper, the Markov state model which ca...

Reliability Centered Maintenance(RCM) is one of most widely used methods in the modern power system to schedule a maintenance cycle and determine the priority of inspection. In order to apply the RCM method to the Smart Grid, a precedence study for the new structure of rearranged system should be performed due to introduction of additional installation such as renewable and sustainable energy r...