نتایج جستجو برای: rbl 2h3

تعداد نتایج: 1142  

Journal: :Journal of immunology 2006
Stephan L Brown Venkatakrishna R Jala Sandeep K Raghuwanshi Mohd W Nasser Bodduluri Haribabu Ricardo M Richardson

Platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycerolphosphocholine; PAF) induces leukocyte accumulation and activation at sites of inflammation via the activation of a specific cell surface receptor (PAFR). PAFR couples to both pertussis toxin-sensitive and pertussis toxin-insensitive G proteins to activate leukocytes. To define the role(s) of G(i) and G(q) in PAF-induced leukocyte respon...

2016
Hwa-Jin Chung Jinho Lee Joon-Shik Shin Me-Riong Kim Wonil Koh Min-Jeong Kim Jae-Woong Lee Eun Jee Kim In-Hee Lee Won Kyung Kim Yoon Jae Lee Sang Kook Lee In-Hyuk Ha

BACKGROUND Bee venom (BV), a type of toxin extracted from honeybees (Apis mellifera), has been empirically and widely used to treat inflammatory diseases throughout Asia. Essential BV (eBV) was developed by removing phospholipase A2 (PLA2) and histamine to lower occurrence of allergic reaction. This study investigated the anti-allergic and anti-inflammatory activities of eBV in vitro and in viv...

Journal: :Journal of Genome Editing and Regulation 2022

CRISPR/Cas9-mediated base editing introduces point mutations in cellular DNA by exploiting target-specific single guide RNA (sgRNA) along with a genetically modified Cas9. Existing plasmid vectors for sgRNA expression contain either fluorescent marker or an antibiotic resistance cassette but not both, preventing simultaneous monitoring and enrichment of transfected host cells. In this study, we...

Journal: :Journal of Investigative Dermatology 2022

Despite the high prevalence of chronic dermatitis and accompanied intractable itch, therapeutics that specifically target itching have low efficacy. Increasing evidence suggests TLRs contribute to immune activation neural sensitization; however, their roles in itch remain elusive. Here, we show RBL-2H3 mast cell line expresses TLR4 treatment with a antagonist opposes LPS dependent increase mRNA...

Journal: :Proceedings for Annual Meeting of The Japanese Pharmacological Society 2018

Journal: :The Journal of biological chemistry 1995
R M Richardson H Ali E D Tomhave B Haribabu R Snyderman

To define the molecular mechanisms of cross-regulation among chemoattractant receptors, we stably coexpressed, in a rat basophilic leukemia (RBL-2H3) cell line, epitope-tagged receptors for the chemoattractants formylmethionylleucylphenylalanine (fMLP), a peptide of the fifth component of the complement system (C5a), and interleukin-8 (IL-8). All the expressed receptors underwent homologous pho...

Journal: :Molecular biology of the cell 1998
B S Wilson J R Pfeiffer A J Smith J M Oliver J A Oberdorf R J Wojcikiewicz

Rat basophilic leukemia (RBL-2H3) cells predominantly express the type II receptor for inositol 1,4,5-trisphosphate (InsP3), which operates as an InsP3-gated calcium channel. In these cells, cross-linking the high-affinity immunoglobulin E receptor (FcepsilonR1) leads to activation of phospholipase C gamma isoforms via tyrosine kinase- and phosphatidylinositol 3-kinase-dependent pathways, relea...

Journal: :Molecular pharmacology 2001
Z Gao B S Li Y J Day J Linden

Adenosine accumulates to high levels in inflamed or ischemic tissues and activates A3 adenosine receptors (ARs) on mast cells to trigger degranulation. Here we show that stimulation of rat basophilic leukemia (RBL)-2H3 mast-like cells with the A3 AR agonists N6-(3-iodo)benzyl-5'-N-methylcarboxamidodoadenosine (IB-MECA; 10 nM) or inosine (10 microM) stimulates phosphorylation of protein kinase B...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید