Azelaic acid and its esters, the azelates, occur naturally in organisms ranging from plants to humans. We have shown that diethyl azelate (DEA) exhibits a broad range of immunomodulatory activities vitro vivo, mitigates insulin resistance. To further investigate therapeutic utility DEA, we evaluated mutagenicity Salmonella typhimurium strains, examined metabolism DEA rat, dog, monkey human prim...
