نتایج جستجو برای: rat ovarian granulosa cells

تعداد نتایج: 1649442  

Journal: :Endocrinology 2004
James Greenaway Kristin Connor Hanne G Pedersen Brenda L Coomber Jonathan LaMarre Jim Petrik

Vascular endothelial growth factor (VEGF) is a potent mitogen and cytoprotective factor for vascular endothelial cells. Although VEGF is ubiquitously expressed, its role in nonvascular tissues is poorly understood. VEGF interacts with various cell surface receptors to mediate its cellular effects. It previously has been thought that the VEGF receptor Flk-1/KDR, its main signaling receptor, was ...

A. AhangarPour , H. Hashemitabar , M. Mesbah , N. Erfani Majd , N. Salamat ,

Vitellogenic stage carp ovaries were collected aseptically and the cells of ovarian follicles were dispersed by trypsin treatment and cultivated as monolayer. Control cultures were grown in medium M199 alone. Media for experimental cultures were supplemented either with 100 µl ml-1 of CPH and CPS-carp GnRH (cultivated pituitary cell secretion affected by 10-6, 10-8, 10-10 M carp GnRH)....

Journal: :Reproductive biology 2006
Jan Kotwica Michał Wróbel Jarosław Młynarczuk

Ovarian, endometrial and myometrial cells and strips of longitudinal myometrium from cows on defined days of estrous cycle were treated for 24-72 h with different doses (1-100 ng/ml) of PCBs mixture (Aroclor 1248) or with one of PCB congeners (126, 77, 153). The administered doses of PCBs neither affected the viability of cells nor influenced the ovarian steroidogenesis as measured by progester...

Journal: :Domestic animal endocrinology 1995
L J Spicer S E Echternkamp

Insulin and insulin-like growth factors (IGFs) have direct effects on cultured ovarian cells. These effects include stimulation of granulosa cell mitogenesis, granulosa and luteal cell progesterone production, and thecal cell androgen production and appear similar among species. However, species differences exist with regard to insulin and IGF-I effects on granulosa cell estradiol production. I...

Journal: :Endocrinology 2001
Yoshihiro Nishi Toshihiko Yanase Yi-Ming Mu Koichi Oba Isao Ichino Masayuki Saito Masatoshi Nomura Chizu Mukasa Taijiro Okabe Kiminobu Goto Ryoichi Takayanagi Yoshiko Kashimura Masafumi Haji Hajime Nawata

We established a steroidogenic human ovarian granulosa-like tumor cell line, designated KGN, from a patient with invasive ovarian granulosa cell carcinoma. KGN had a relatively long population doubling time of about 46.4 h and had an abnormal karyotype of 45,XX, 7q-, -22. A steroid analysis of the cultured medium by RIA performed 5 yr after the initiation of culture showed that KGN was able to ...

Journal: :Reproduction, nutrition, development 2006
Zhengchao Wang Lingmei Pan Jinbiao Luo Hao Wang Fangxiong Shi

Inactivation of the cyclic nucleotide signal in granulosa cells depends on a complex array of cyclic nucleotide phosphodiesterases (PDE). In order to examine the role of PDE in cyclic AMP (cAMP) signaling in granulosa cells, the present study examined the expression of PDE4D proteins and regulation of cAMP-PDE activities in cultured rat granulosa cells. The results of immunoblot analyses showed...

2016
Sakineh Kaboli Kafshgiri Kazem Parivar Javad Baharara Mohammad Amin Kerachian Nasim Hayati Roodbari

OBJECTIVES Pesticides has wide range of infertility in female reproductive. This study was done to evaluate the effect of movento pesticide on development of granulosa cells and ovarian follicles and FoxO1 and Vnn1 gene expression in BALB/c mice. MATERIALS AND METHODS In this study 40 healthy BALB/c mice 5-6 weeks age were used. Animals were randomly allocated into four groups. Control (witho...

Journal: :Reproductive biology and endocrinology : RB&E 2007
Veronica Rey-Ares Nikolai Lazarov Dieter Berg Ulrike Berg Lars Kunz Artur Mayerhofer

BACKGROUND High levels of dopamine (DA) were described in human ovary and recently evidence for DA receptors in granulosa and luteal cells has been provided, as well. However, neither the full repertoire of ovarian receptors for DA, nor their specific role, is established. Human granulosa cells (GCs) derived from women undergoing in vitro fertilization (IVF) are an adequate model for endocrine ...

Journal: :iranian journal of toxicology 0
n tawakal department of anatomy, king edward medical university, lahore pakistan a mubarak khalid department of anatomy, king edward medical university, lahore pakistan u farooq khan lahore general hospital, lahor pakistan k raees ahmad department of biological sciences, university of sargodha, sargodha, pakistan asmatullsh department zoology, university of the punjab, lahor, pakistan

introduction:artifical sourace of radiation have increased worldwide average annual exposure of mankind and could especially affect rapidly dividing cells in gonads. since, radiation sensitivities of different components of primordial follicles, and the time required for their deplation have not been morphologically eatablished we decided to estimate the time required for depletion of primordia...

2014
Kata Osz Michelle Ross Jim Petrik

BACKGROUND Ovarian angiogenesis is a complex process that is regulated by a balance between pro- and anti-angiogenic factors. Physiological processes within the ovary, such as folliculogenesis, ovulation, and luteal formation are dependent upon adequate vascularization and anything that disrupts normal angiogenic processes may result in ovarian dysfunction, and possibly infertility. The objecti...

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