Background and Aim: Recurrent aphthous stomatitis (RAS) is one of the most common lesions in the oral mucosa. The etiopathogenesis of RAS is not clear. RAS is multifactorial, and several factors can contribute to RAS development. This study aimed to evaluate the RAS prevalence and some related factors in 12-17-year-old schoolchildren in Zahedan City (Southeast of Iran). Materials and Methods: ...

We first found a partial coding region of a new YPT1-related human gene in an aberrant cDNA clone fused with an anti-sense C_ region transcript of the immunoglobulin K gene, isolated from a Burkitt lymphoma cell line KOBK101 (1) carrying a t(2;8) translocation. Then, the complete cDNA clone was isolated from a human promonocytic cell line U-937 (2). The nucleotide and the deduced amino acid seq...

Signaling proteins from the same family can have markedly different roles in a given cellular context. Here, we show that expression of one hundred constitutively active human small GTPases induced cell morphologies that fell into nine distinct classes. We developed an algorithm for pairs of classes that predicted amino acid positions that can be exchanged to create mutants with switched functi...

Unique among the phospholipase C isozymes, the recently identified phospholipase C-epsilon (PLC-epsilon) contains an amino-terminal CDC25 domain capable of catalyzing nucleotide exchange on Ras family GTPases as well as a tandem array of Ras-associating (RA) domains near its carboxyl terminus that are effector binding sites for activated H-Ras and Rap. To determine whether other small GTPases a...

abstract comparing with the numerous studies carried out in other countries, information on apoidea superfamily in iran is scare. during a faunistic survey of pollinator bees associated with alfalfa fields in mashhad and chenaran regions in 2010, numerous specimens of apoidea superfamily were collected and identified. among the identified species, anthidium diadema (latreille, 1809) is record f...

A Ras homologue member I (ARHI) is a novel imprinted tumor suppressor gene whose expression is frequently lost in breast and ovarian cancers. This small GTP-binding protein is a member of the Ras superfamily with significant homology to both Ras and Rap. Unlike the Ras oncogene, however, ARHI inhibits tumor cell growth. To elucidate the mechanisms by which ARHI inhibits cancer growth, we screen...