نتایج جستجو برای: rapid kindling

تعداد نتایج: 305038  

2016
Kentaro Tokudome Takahiro Okumura Saki Shimizu Tomoji Mashimo Akiko Takizawa Tadao Serikawa Ryo Terada Shizuka Ishihara Naofumi Kunisawa Masashi Sasa Yukihiro Ohno

Synaptic vesicle glycoprotein 2A (SV2A) is a prototype synaptic vesicle protein regulating action potential-dependent neurotransmitters release. SV2A also serves as a specific binding site for certain antiepileptics and is implicated in the treatment of epilepsy. Here, to elucidate the role of SV2A in modulating epileptogenesis, we generated a novel rat model (Sv2a(L174Q) rat) carrying a Sv2a-t...

Journal: :Behavioral neuroscience 1999
L E Kalynchuk J P Pinel D Treit

Long-term amygdala kindling produces substantial changes in emotional behavior in rats. The purpose of these experiments was to determine whether kindling-induced emotionality is fundamentally defensive or aggressive in nature. In Experiment 1, amygdala-kindled rats tested as intruders in a resident-intruder paradigm preferred an active defense strategy (i.e., defensive upright stance, jump att...

Journal: :Journal of the Turkish Epilepsi Society 2015

Journal: :Brain research. Molecular brain research 1991
G C Teskey B G Atkinson D P Cain

Kindling is a permanent form of brain change that results from repeated elicitation of epileptiform neural activity. c-fos has been proposed as the gene responsible for turning on molecular events that might underlie the long-term neural changes that occur during kindling. This study investigated the enhancement of c-fos levels following kindled seizures and the role of c-fos in the plastic cha...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1997
J Bengzon Z Kokaia E Elmér A Nanobashvili M Kokaia O Lindvall

Neuronal apoptosis was observed in the rat dentate gyrus in two experimental models of human limbic epilepsy. Five hours after one hippocampal kindling stimulation, a marked increase of in situ terminal deoxynucleotidyltransferase-mediated dUTP nick-end labeling (TUNEL) of fragmented DNA was observed in nuclei located within and on the hilar border of the granule cell layer and in the polymorph...

Journal: :Neuroscience 2001
R Gutiérrez P Leff H Romo-Parra R Acevedo B Antón

The role of Orphanin-FQ/nociceptin in synaptic plasticity was assessed by its potency in modulating kindling epileptogenesis in vivo, and feed-forward inhibition in hippocampal recordings in vitro. In addition, a specific rabbit antiserum against this peptide was obtained and the immunohistochemical distribution of nociceptin was determined in rat brain slices. After the establishment of kindli...

Journal: :Molecules 2011
Vesna Ivetic Svetlana Trivic Marija Knezevic Pogancev Mira Popovic Janka Zlinská

The purpose of this study was to investigate the effects of treatment with water, n-butanol and ether extracts of Hypercom perforatum L. on epileptogenesis in rabbits. Animals from the control group received solvent-ethanol, and the kindling model of epilepsy was used. Epileptic focus was induced in Chinchilla rabbits by stimulation of the hippocampus. The following parameters were determined: ...

Journal: :Clinical psychology review 2011
Rachel E Bender Lauren B Alloy

Most life stress literature in bipolar disorder (BD) fails to account for the possibility of a changing relationship between psychosocial context and episode initiation across the course of the disorder. According to Post's (1992) influential kindling hypothesis, major life stress is required to trigger initial onsets and recurrences of affective episodes, but successive episodes become progres...

Journal: :Psychiatria polska 2009
Tomasz Zyss

Except for pharmacotherapy--electroconvulsive treatment ECT is the most important therapy form of depressive disorders. Although ECT elicits a paroxysmal activity in the brain, the convulsive electric stimulation ECT leads however at least to a anti-convulsive effect (e.g.: elevation of the threshold level). The submitted work undertakes a trail of analysis about kindling-another neurophysiolog...

2017
Xinjian Zhu Jingde Dong Bing Han Rongrong Huang Aifeng Zhang Zhengrong Xia Huanhuan Chang Jie Chao Honghong Yao

Epilepsy is a chronic neurological disease which is usually associated with psychiatric comorbidities. Depsression and cognition impairment are considered to be the most common psychiatric comorbidities in epilepsy patients. However, the specific contribution of epilepsy made to these psychiatric comorbidities remains largely unknown. Here we use pentylenetetrazole (PTZ) kindling, a chronic epi...

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