Delayed renewal process and delayed renewal reward process are introduced in the framework of uncertainty theory and their uncertainty distributions are provided. Furthermore, delayed renewal theorem on the limit value of the expected renewal rate of the process and delayed renewal reward theorem on the limit value of the long-run expected reward per unit time are presented. At last, some examp...

The Arabic subject contents at Islamic intermediate schools in Indonesia are still need to be developed. This is necessary order support and achieve the learning objectives Indonesia. As subjects mostly popular studied every Indonesia, especially where there dormitories. purpose of this article construct educational content renewal language for sake achievement used descriptive analytics method...

dimethoate (organophosphate insecticide) and lambda-cyhalothrin (synthetic pyrithroid) aretwo frequently used pesticides due to their high effectiveness and rapid breakdown into environmentally safeproducts. the aim of this present study was to assess and compare the acute toxicity of dimethoate(rogor30%ec) and lambda-cyhalothrin (5%ec) on labeo rohita (hamilton). acute toxicity bioassay wascar...

AIMS Although pharmacological interventions that mobilize stem cells and enhance their homing to damaged tissue can limit adverse post-myocardial infarction (MI) remodelling, cardiomyocyte renewal with this approach is limited. While experimental cell cycle induction can promote cardiomyocyte renewal following MI, this process must compete with the more rapid processes of scar formation and adv...

The core gene regulatory network (GRN) in embryonic stem cells (ESCs) integrates activities of the pro-self-renewal factors Oct4 (Pou5f1), Sox2 and Nanog with that of an inhibitor of self-renewal, Tcf7l1 (Tcf3). The inhibitor function of Tcf7l1 causes dependence on extracellular Wnt/β-catenin signaling activity, making its embryonic role within the ESC GRN unclear. By analyzing intact mouse emb...

Stem cells in adult tissues are constantly exposed to genotoxic stress and also accumulate DNA damage with age. However, it remains largely unknown how DNA damage affects both stem cell self-renewal and differentiation. In this study, we show that DNA damage retards germline stem cell (GSC) self-renewal and progeny differentiation in a Lok kinase-dependent manner in the Drosophila ovary. Both h...

Taste stimuli are transduced by taste buds and transmitted to the brain via afferent gustatory fibers. Renewal of taste receptor cells from actively dividing progenitors is finely tuned to maintain taste sensitivity throughout life. We show that conditional β-catenin deletion in mouse taste progenitors leads to rapid depletion of progenitors and Shh+ precursors, which in turn causes taste bud l...

Hematopoietic stem cells (HSCs) are rare residents of the bone marrow responsible for the lifelong production of blood cells. Regulation of the balance between HSC self-renewal and differentiation is central to hematopoiesis, allowing precisely regulated generation of mature blood cells at steady state and expanded production at times of rapid need, as well as maintaining ongoing stem cell capa...

BACKGROUND Mesenchymal progenitor cells (MPCs) have been isolated from a variety of connective tissues, and are commonly called "mesenchymal stem cells" (MSCs). A stem cell is defined as having robust clonal self-renewal and multilineage differentiation potential. Accordingly, the term "MSC" has been criticised, as there is little data demonstrating self-renewal of definitive single-cell-derive...

The existence of bladder cancer stem cells (BCSC) has been suggested to underlie bladder tumor initiation and recurrence. Sonic Hedgehog (SHH) signaling has been implicated in promoting cancer stem cell (CSC) self-renewal and is activated in bladder cancer, but its impact on BCSC maintenance is unclear. In this study, we generated a mAb (BCMab1) against CD44(+) human bladder cancer cells that r...