This is a multi-center qualitative study embedded within larger multiphase feasibility investigating the management benign paroxysmal positional vertigo (BPPV) in acute traumatic brain injury(TBI). Evidence has shown methods have place studies as they can improve validity of future trial. Our primary objective was to explore acceptability trial processes such recruitment, randomization and inte...

Background: Chronic Pain (CP) is a crucial determinant for disability in older adults. CP amplifies the impact of other common age-related diseases and increases cardiovascular risk. Physical exercise can improve CP. Randomized Controlled Trials (RCTs) with high-intensity adults excluded people Moderate Illness (MCI) Objective: This study aimed at evaluating an RCT whether moderate training chr...

An alternative hypothesis, defined as the assumed clinically meaningful treatment effect at primary endpoint, is determined when a randomized controlled trial (RCT) designed. Nevertheless, most researchers conducting RCTs for superiority very often disregard evaluating hypothesis. Since clinical trials are designed to demonstrate statistical significance of in that fail show this, aspects resul...

BACKGROUND Despite sparse pediatric data on effectiveness, the majority of critically ill children receive medications to prevent gastrointestinal (GI) bleeding. Stress ulcer prophylaxis may have unintended consequences-increasing the risk of nosocomial infections-which may be more serious and common than the bleeding which these drugs are prescribed to prevent. Randomized controlled trials (RC...

In a recent issue of CHEST (June 2015), we read with interest the randomized controlled trial (RCT) by Kirakli et al comparing adaptive support ventilation (ASV) with pressure assist/control ventilation (P-ACV) for the entire duration of mechanical ventilation (MV) in a cohort of 229 patients in the medical ICU. The study showed a shorter duration of the weaning process and total MV in the ASV ...

RESEARCH DESIGN AND METHODS — After completion of a 6-month randomized controlled trial (RCT) evaluating CGM in children, adolescents, and adults with type 1 diabetes, CGM was initiated in the trial’s control group with less intensive training and follow-up than was included in the RCT. Subjects had an outpatient training session, two follow-up phone calls, and outpatient visits at 1, 4, 13, an...

To evaluate the intervention effects of randomized controlled trials (RCT) involved in theoretical efficacy and actual clinical outcome (effectiveness). Pragmatic-Explanatory Continuum Indicator Summary (PRECIS) is a tool to help researchers make decisions in study design which is consistent with the intended purpose of their trial which can be used in the design of RCT to balance the internal ...

The importance of treating traumatic brain injury (TBI) is well known worldwide. Although many studies have been conducted in this topic, there is still much uncertainty about the effectiveness of surgical treatment in TBI. Recently, good randomized controlled trial (RCT) papers about the effectiveness of decompressive craniectomy (DC) in TBI has been published. In this article, we will review ...

OBJECTIVE Patient-specific template-guided (TG) pedicle screw placement currently achieves the highest reported accuracy in cadaveric and early clinical studies, with reports of reduced use radiation less surgical time. However, a randomized controlled trial (RCT) eliminating potential biases is lacking. This study compares TG standard freehand (FH) insertion techniques an RCT. METHODS Twenty-f...

INTRODUCTION As patients with rheumatoid arthritis (RA) receive treatment with anti-tumour necrosis factors over several years, it is important to evaluate their long-term safety and efficacy. The objective of this study was to examine the safety and benefits of certolizumab pegol (CZP)+methotrexate (MTX) treatment for almost 5 years in patients with RA. METHODS Patients who completed the 24-...