The invention of the laser in 1960 has been a very important milestone for our presentday society. This remarkable new light source not only triggered a revolution in science and technology but also gave rise to a significant improvement of the quality of our daily life. An important type of laser is the so-called Raman laser, the lasing mechanism of which is based on Stimulated Stokes Raman Sc...

To explore the effectiveness of Raman spectra to diagnose brain cancer glioblastoma multiforme (GBM), we investigated the Raman spectra of single cell from four different GBM cell lines developed from four different patients and analyzed the spectra. The Raman spectra of brain cancer (GBM) cells were similar in all these cell lines. The results indicate that Raman spectra can offer the experime...

We report the first observation of Raman optical activity (ROA) by coherent anti-Stokes Raman scattering. Thanks to the more freedom of polarization configurations in coherent anti-Stokes Raman scattering than in spontaneous Raman spectroscopy, the contrast ratio of the chiral signal to the achiral background has been improved markedly. For (-)-β-pinene, it is 2 orders of magnitude better than ...

We report optical near-field Raman imaging with subdiffraction resolution (approximately 120 nm) without field enhancement effects. Chemical discrimination on tetracyanoquinodimethane organic thin films showing localized salt complexes is accomplished by detailed Raman maps. Acquisition times that are much shorter than previously reported are due to the high Raman efficiency of the materials an...

Although ground-base Raman lidars are widely used for atmospheric observations, the capabilities of airborne Raman lidar is not fully explored. Here we presented two recently developed airborne Raman lidar systems for the studies of atmospheric boundary layer process, aerosols, and clouds. The systems are briefly introduced. Observation examples are presented to illustrate the unique observatio...

The visible (532 and 442 nm) and UV (325 nm) Raman spectra of bulk mixed metal oxides (metal molybdates and metal vanadates) were compared on the same spectrometer, for the first time, to allow examination of how varying the excitation energy from visible to UV affects the resulting Raman spectra. The quality of the Raman spectra was found to be a strong function of the absorption properties of...

We have used a remote time-resolved telescopic Raman system equipped with 532 nm pulsed laser excitation and a gated intensified CCD (ICCD) detector for measuring Raman spectra of a number of minerals at high temperature to 970 K. Remote Raman measurements were made with samples at 9-meter in side a high-temperature furnace by gating the ICCD detector with 2 micro-sec gate to minimize interfere...

We employed deep UV (DUV) Raman spectroscopy for characterization of molecular photodamage in cells. 244 nm light excitation Raman spectra were measured for HeLa cells exposed to the excitation light for different durations. In the spectra obtained with the shortest exposure duration (0.25 sec at 16 µW/µm(2) irradiation), characteristic resonant Raman bands of adenine and guanine at 1483 cm(-1)...

High spatial resolution Raman maps of fixed cells in an aqueous environment are reported. These maps were obtained by collecting individual Raman spectra via a Raman microspectrometer in a raster pattern on a 0.5-microm grid and assembling pseudocolor maps from the spectral hypercubes by multivariate methods. The Raman maps show the nucleus and the nucleoli of cells as well as subcellular organ...

Raman spectroscopy provides label-free biochemical information from tissue samples without complicated sample preparation. The clinical capability of Raman spectroscopy has been demonstrated in a wide range of in vitro and in vivo applications. However, a challenge for in vivo applications is the simultaneous excitation of auto-fluorescence in the majority of tissues of interest, such as liver,...