This little book gives a short account of cases treated by the author with radium in the hope that it may draw the attention of the general practitioner and student to the conditions in which this valuable therapeutic agent may be of use. The first portion of the work is devoted to a short summary of the physical problems connected with radium, including apparatus, screening, methods of applica...

The largest fraction of the natural radiation exposure we receive comes from a radioactive gas, radon and its decay products (nearly 50%). The radon gas can enter to the body via respiring, drinking and eating and caused damage to respiratory and digestion systems. Also radium-226 is widely distributed in the environment. When a person ingests radium, this element deposits in bones and cause to...

Very little is known concerning the changes that occur in living tissue following the injection of solutions of an “active deposit’’ of radium emanation. This investigation was undertaken to determine what changes occur in the principal organs of the animal body following such a treatment, and to afford data that might act as a guide in the treatment of certain types of cancer, in which the sol...

In 2004, docetaxel was approved for the treatment of metastatic castration-resistant prostate cancer (mCRPC). For the next several years, there was a lull in drug approvals. However, from 2010 onwards, 5 additional therapies have been approved on the basis of showing a survival benefit in phase III studies. These agents include sipuleucel-T, cabazitaxel, abiraterone, enzalutamide and (most rece...

Prostate cancer is the most common malignant disease in men. Several therapeutic agents have been approved during the last 10 years. Among them, radium-223 dichloride (Xofigo®) is a radioactive isotope that induces irreversible DNA double-strand breaks and consequently tumor cell death. Radium-223 dichloride is a calcium-mimetic agent that specifically targets bone lesions. Radium-223 dichlorid...

Using radium (Ra) isotopes and nutrient analyses, we found that submarine groundwater discharge (SGD) is an important source of ‘‘new’’ nutrients, particularly nitrogen, to coral reefs around the world. Nitrogen input estimates associated with SGD range from 3 to 800 mmol h21 per meter of shoreline. The use of Ra isotopes allows us to quantify the inorganic nitrogen input from this source of nu...

manner that a medical practitioner will have not only no difficulty in following the author, but also will positively enjoy reading him. The author first of all deals with the physics of radium: next the apparatus and means of application, then the sensitivity of the tissues to radium, and. proceeds to deal with malignant growths in various situations, which are suitable for radium therapy. The...

The discovery of radium by Madame Curie in 1898 opened up a field of physical research the limits of which it is impossible to see. Although it was found at an early stage that radium had a definite action upon living tissues, this appeared to be purely destructive, and it is only recently that the selective action of radium upon cancer cells has been adequately demonstrated. Depending as it do...