Abstract There is mounting evidence that tumor microenvironmental pressure selects for somatic genetic alterations contribute to the formation of distinct morphological characteristics, captured on radiology scans as radio-phenotypes. Such phenotypic variations are a source heterogeneity in clinical manifestation tumors same histology across patients, and part, their heterogeneous responses the...

Abstract Understanding the immune microenvironment in pediatric low-grade glioma (pLGG) patients may help identification of who benefit from anti-tumor immunotherapies. However, surgical resection is not feasible for many pLGG tumors certain anatomical locations. Therefore, developing non-invasive tools that characterize tumor prior to therapeutic interventions could contribute stratification a...

Aim: We compare the diagnostic approaches: surgeon prediction, prediction plus ultrasound imagining (US) as first-line imaging modality, and magnetic resonance (MRI) second-line for suspected pediatric appendicitis. 
 Methods: Three hundred sixty-one patients with a clinically appendicitis were prospectively divided into three groups by type of approach. Results: A total 51 diagnosed via o...

Algorithms to predict ischemic tissue fate based on acute stroke MRI typically utilized data at a single time point. The goal of this study was to investigate the potential improvement in prediction accuracy when incorporating MRI diffusion data from multiple time points during acute phase to improve prediction accuracy. This study was carried out using MRI data from rats subjected to permanent...

mri of the breast has evolved as a non-invasive imaging modality and is ideally suited for several indications e.g. pre-operative staging and screening in women at increased risk for breast cancer. the widespread use opens also the discussion on over-diagnosis if only 20 - 30 out of 100 mri - guided breast biopsies lead to the diagnosis of breast cancer. thus mri based strategies are needed to ...

OBJECTIVE In the treatment of spinal metastases with stereotactic body radiation therapy (SBRT), vertebral compression fracture (VCF) is a common and potentially morbid complication. Better methods to identify patients at high risk radiation-induced VCF are needed evaluate prophylactic measures. Radiomic features from pretreatment imaging may be employed more accurately predict VCF. The objecti...