Isosorbide dinitrate (ISDN) is an effective drug in treatment of angina pectoris. In this study a new generation of electron capture detector (non-radioactive) with a short, non-polar and wide-bore column was used for analysis of ISDN in human serum. ISDN was extracted from serum by a mixture of ether and ethyl acetate and concentrated at room temperature. The method was linear between 5-50...

BACKGROUND & OBJECTIVES In recent years, brachytherapy involving permanent radioactive seed implantation has emerged as an effective modality for the management of cancer of prostate. 125 I-Ocu-Prosta seeds were indigenously developed and studies were carried out to assess the safety of the indigenously developed 125 I-Ocu-Prosta seeds for treatment of prostate cancer. METHODS Animal experime...

This paper deals with the study of radioactive waste generation and their treatment techniques. The wastes that are generated during the front and back end of the nuclear power production are classified are low, intermediate and high level waste. The various existing process for the treatment for the waste like, reprocessing, pyroprocessing, transmutation, and options available for the disposal...

The mechanism of the previously reported cytotoxicity of liposomes containing plant phosphatidylinositol (PI) against numerous tumor cell lines was examined in detail by using liposomes containing synthetic PI specifically labeled either with radioactive myo-inositol, or in the sn-2 position with radioactive linoleic acid, oleic acid, or arachidonic acid. The uptake of liposomal PI by N4TG1 neu...

Abstract Safe storage of radioactive materials is based on three universal radiation protection principles. Justification, optimization and dose limits are applicable to the risk assessment, acknowledging hazards in each procedure delivery, usage, disposal materials. Failure Modes Effects Analysis method (FMEA) developed for evaluation common practices. In this work FMEA exploited radiological ...

Incorporation of radioactive alanine into chromatin-bound subfractions of H1 histone was studied in HeLa cells synchronized by the double thymidine block technique. The subfractions were resolved into three chromatographic peaks by Biorex-70. In the period 5-7 h after release from the thymidine block, peaks I and III showed twice as much incorporation as they did in the period 1-3 h after relea...

A compound that could be converted to prostaglandin F(2alpha) by mild chemical reduction was formed by human platelets in response to arachidonic acid, collagen, or L-epinephrine. It was present in maximal amounts at about 1 min after addition of arachidonic acid or collagen to platelet-rich plasma. Its initial formation appeared to precede platelet aggregation by these agents and was closely c...

DNA synthesis was investigated in human malignant mela noma cells. The DNA was extracted in a neutral nondenaturing buffer at 25°and characterized by agarose gel electrophoresis. Radioactive DNA pulse labeled for 10 to 30 min was released from the chromosomes in the form of double-stranded frag ments. The release of the fragments from the chromosomes is prevented by lysing the cells at 0°inst...

Patients recently treated with radioactive isotopes may present problems or even hazards during physical examination, operation or autopsy, especially following the use of iodine isotopes and 198Au. 32P is rarely a significant hazard. Contamination of victims of radiation accidents may be a problem initially, but they are usually promptly decontaminated. Guidance of the hospital's radiation saf...

Traditionally, the concept of ALARA has been the basis for limitation and optimisation of releases of radioactive substances from nuclear power reactors in order to protect human health. In recent years, it has been discussed whether the ALARA principle can be applied also to protect the environment. For the protection of the environment, in particular for non-nuclear pollutants, the precaution...