Protein misfolding and aggregation are associated with many neurodegenerative diseases, including Huntington's disease. The cellular machinery for maintaining proteostasis includes molecular chaperones that facilitate protein folding and reduce proteotoxicity. Increasing the protein folding capacity of cells through manipulation of DNAJ chaperones has been shown to suppress aggregation and amel...

Over the past three decades of intense research on the contribution of viral and host factors determining the variability in HIV-1 infection outcome, HIV pathogenesis is still a fascinating topic that requires further study. An understanding of the exact mechanism of how these factors influencing HIV pathogenesis is critical to the development of effective strategies to prevent infection. Signi...

In Indonesia, cattle feces (CF) and water hyacinth (WH) plants are abundant but have not been widely revealed. The use of microorganisms as decomposers in the fermentation process has applied, so researchers interested studying further. This study was to evaluate effect combination CF with WH on composting by applying white-rot fungal (WRF) (Ganoderma sp) microorganism a decomposer. A number si...

during 1997-1998, five different doses of emulsifiable mayonnaise oil (1 , 1.5 , 2 , 2.5 and 3 percents) and a control in three replications were tested against nymphal stages of olive psylla (euphyuura olivina) in late april (a few days before blooming) in a complete randomized block design. population densities of nymphal stages of pest were counted one day before and five days after oil appl...

to understand the effects of salinity stress on four different growth stages of sorghum, a greenhouse experiment with 10 treatments, considering all possible combinations of salinity stress and salt- free periods was carried out. the four growth stages for stress application included: emergence until growing point differentiation, growing point differentiation until half bloom, half bloom until...

CCR5-using (R5) human immunodeficiency virus type 1 (HIV-1) is a major viral population that is transmitted by sexual intercourse and that replicates in infected individuals during the asymptomatic stage of HIV-1 infection, suggesting that agents effective against R5 HIV-1 can be expected to prevent viral transmission and delay disease progression. However, R5 HIV-1 is unable to replicate in hu...