INTRODUCTION 'No evidence of disease activity' (NEDA) is increasingly used as a treatment target with disease-modifying drugs for relapsing multiple sclerosis. METHODS This post-hoc analysis of the randomised EVIDENCE trial compared interferon beta-1a injected subcutaneously three times weekly (IFN β-1a SC tiw) with interferon β-1a injected intramuscularly once weekly (IFN β-1a IM qw) on NEDA...

INTRODUCTION Exenatide is gradually released from exenatide once weekly (QW) microspheres, and at steady state, consistently controls glycated hemoglobin (HbA1c) in patients with type 2 diabetes (T2D). This post hoc analysis examined the timing to onset of clinical responses and their correlations with exenatide concentrations after initiation of exenatide QW in patients with T2D. METHODS Tri...

BACKGROUND The EVIDENCE (Evidence of Interferon Dose-Response: European North American Comparative Efficacy) Study demonstrated that patients with multiple sclerosis (MS) who initiate interferon beta-1a therapy with 44 microg 3 times weekly (TIW) were less likely to have a relapse or activity on magnetic resonance imaging (MRI) compared with those who initiate therapy at a dosage of 30 microg 1...

The interaction between excitonic and phonon modes in semiconductor nanostructures leads to both relaxation of the excitonic population as well as to pure dephasing of the optical polarization. In small quantum dots, where the interstate relaxation is tiny, clear signatures of pure dephasing effects have been measured, see e.g. the extensive work done in [1] and [2]. In this case, an accurate t...

OBJECTIVES The objective of this study was to assess the humanistic impact of ankylosing spondylitis (AS), and compare the effect of etanercept 50 mg once-weekly (QW), etanercept 25 mg twice-weekly (BIW) and placebo on patient-reported outcomes (PROs). METHODS In a 12-week, double-blind, placebo-controlled multicenter study, 356 patients with active AS received etanercept 50 mg QW, etanercept...

The energy level structure of a step-like GaInNAsSb/GaNAs/GaAs quantum well sQWd has been investigated by photoreflectance sPRd spectroscopy and was analyzed by theoretical calculations. In the active region of this structure, i.e., GaInNAsSb/GaNAs QW, we have observed PR resonances related higher order QW transitions in addition to the ground state transition. Based on calculations from experi...

We have used high resolution transmission electron microscopy (HRTEM), aberration-corrected quantitative scanning transmission electron microscopy (Q-STEM), atom probe tomography (APT) and X-ray diffraction (XRD) to study the atomic structure of (0001) polar and (11-20) non-polar InGaN quantum wells (QWs). This paper provides an overview of the results. Polar (0001) InGaN in QWs is a random all...

PURPOSE A phase I study was conducted to evaluate the pharmacokinetics, pharmacodynamics, safety, and tolerability of R1507-a fully human IgG1 type monoclonal antibody directed against the human insulin-like growth factor-I receptor. EXPERIMENTAL DESIGN Patients with advanced solid tumors were assigned to receive i.v. R1507 weekly (qW), starting with 1 mg/kg. Subsequent cohorts were dosed at ...

The interdiffusion of GaxIn12xN0.04As0.96 /GaAs single quantum well ~QW! structure with well width of 6 nm is studied theoretically. The as-grown Ga concentration in the QW is chosen to be 0.7 and 0.6 for the operation wavelengths of 1.3 and 1.55 mm, respectively. We studied the effects of interdiffusion on the in-plane strain, confinement potential, and subband energy levels of the QW using Fi...

Despite the ultimate performance of existing cascade lasers, simple interband emitters in mid-infrared (IR) can still be interest as a cheaper and widely tunable alternative for some applications. In this work, we show stimulated emission (SE) at 5–6 ?m wavelength from an optically pumped mercury–cadmium–telluride quantum well (QW) heterostructures temperatures up to 200 K. At lower temperature...