نتایج جستجو برای: quinoxaline derivatives

تعداد نتایج: 105987  

2014
Ursula M Kotyrba Kevin Pröpper Eike-F Sachs Anastasiya Myanovska Tobias Joppe Friederike Lissy George M Sheldrick Konrad Koszinowski Ulf Diederichsen

The DNA bisintercalator triostin A is structurally based on a disulfide-bridged depsipeptide scaffold that provides preorganization of two quinoxaline units in 10.5 Å distance. Triostin A analogues are synthesized with nucleobase recognition units replacing the quinoxalines and containing two additional recognition units in between. Thus, four nucleobase recognition units are organized on a rig...

Journal: :Journal of Enzyme Inhibition and Medicinal Chemistry 2021

Herein, a new wave of bis([1, 2, 4]triazolo)[4,3-a:3',4'-c]quinoxaline derivatives have been successfully designed and synthesised. The synthesised were biologically investigated for their cytotoxic activities against HepG2 MCF-7. Also, the tested compounds further examined in vitro VEGFR-2 inhibitory activity. most promising derivative 23j was its apoptotic behaviour cell lines using flow cyto...

2010
Youssef Ramli Rachid Slimani Hafid Zouihri Saïd Lazar E. M. Essassi

In the mol-ecule of the title compound, C(12)H(12)N(2)O, the quinoxaline ring is planar with an r.m.s. deviation of 0.007 (15) Å. The dihedral angle between the quinoxaline and propenyl planes is 82.1 (2)°. The crystal packing is stabilized by offset π-π stacking between the quinoxaline rings [centroid-centroid distance = 3.8832 (9) Å].

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