A practical and green approach for the one-pot multicomponent synthesis of fused tetrazolo[1,5-a]quinazoline derivatives has been described via the condensation of 5- aminotetrazole, dimedone, and various aldehydes using 1-butyl-3-methylimidazolium tetrachloroaluminate [bmim]Cl/AlCl3, as a catalyst and task-specific ionic liquid medium. The catalyst was showed remarkable advantages in compariso...

A novel synthesis of Iimidazo[1,2-c]quinazoline-5(6H)-thione framework was developed through a three-step reaction starting from benzil. The resulting (2-nitrophenyl)-4,5-diphenyl-1H-imidazole  from the reaction of benzil and different 2-nitrobenzaldehyde, reduction of nitro group and then cyclization reaction with carbon disulfide (CS2). All steps were carried out under easy and user-friendly ...

In the title compound, C15H10Cl2N2O, the dihedral angle between the mean planes of the phenyl ring and the 10-membered quinazoline ring is 63.3 (4)°. In the crystal, pairs of weak C-H⋯O inter-actions link the mol-ecules into centrosymmetric dimers, forming R 2 (2)(10) graph-set ring motifs. In addition, weak π-π stacking inter-actions [minimum centroid-centroid separation = 3.6810 (8) Å] are ob...

In the mol-ecule of the title compound, C21H14N2O3, the quinazoline ring system [maximum deviation = 0.076 (1) Å] makes dihedral angles of 40.57 (9) and 42.31 (11)°, respectively, with the phenyl and 1,3-benzodioxole rings. The dihedral angle between the phenyl ring and the 1,3-benzodioxole ring is 4.34 (10)°. In the crystal, C-H⋯O hydrogen bonds link the mol-ecules into infinite zigzag chains ...

A mild and efficient Cu(2)O-catalyzed domino intramolecular C-N coupling/C-Y (Y = O, S, N) bond formation was successfully achieved. Thus oxazino[3,2-a]indole, thiazino[3,2-a]indole and indolo[2,1-b]quinazoline derivatives were facilely assembled from readily accessible gem-dibromovinyl systems. The protocol is general and practical, affording a variety of the indole-incorporated products in go...

In the title compound, C(15)H(12)FN(3)O(3)·CH(3)OH, the dihedral angle between the quinazoline ring system and the benzene ring is 81.18 (9)°. In the crystal, mol-ecules are linked by N-H⋯O and O-H⋯N hydrogen bonds, generating [10-1] chains of alternating main mol-ecules and solvent mol-ecules. Weak C-H⋯O inter-actions are also observed.

Quinazoline and quinazolinone derivatives display an extensive application in organic pharmaceutical chemistry, they have been used as natural synthetic materials for medicinal chemistry purposes. Here I reported investigation of a new series quinazolin-4(3H)-one ring derivatives. In this context, starting from the methyl anthranilate, six (4a-f) with various aminomethyl moieties at position 2 ...

The synthesis of 2,5-disubstituted 5,6-dihydro-lH-pyrido[l,2-a]quinazoline-l,6-diones (3) by reacting monosubstituted bis 2,4,6-trichlorophenyl malonates (1) with 3-aryl-3,4dihydro-2-methyl-4-quinazolinones (2) is described. Allylation of the pyridoquinazoline 3 c with allylbromide afforded the corresponding 3-allyloxy derivative 4. Certain generalizations of the cleavage processes of this seri...

By combining the structural features of quinazoline and sulfonamides, novel hybrid compounds 2-21 were synthesized using a simple and convenient method. Evaluation of these compounds against different cell lines identified compounds 7 and 17 as most active anticancer agents as they showed effectiveness on the four tested cell lines. The anticancer screening results of the tested compounds provi...