objective(s): this study was performed to investigate the effects of mucosal acidification on mrna expression and protein synthesis of cystathionine gamma lyase (cse), cystathionine beta synthase (cbs), and mucosal release of h2s in gastric mucosa in rats. materials and methods:thirty-two rats were randomly assigned into 4 groups (8 in each), including: the control group, hcl (10 mm) treated gr...

An experiment was conducted to optimize consumption of Zinc and evaluate of Zinc effects on quantitative and qualitative traits of winter wheat under saline soil condition. It was done by three replications in randomized complete block design. The experiment had four treatments as Control without Zn, 40 Kg.ha-1 Zn as ZnSO4, 80 Kg.ha-1 Zn as ZnSO4 in soil and 120 Kg.ha-1 Zn as ZnSO4 in soil. Ele...

sirtuin1 (sirt1) is an enzyme that deacetylates histones and several nonhistone proteins including p53 during stress and plays an important role in the survival of tumor cells. hereby, this study describes the potency of salermide as a sirt1 inhibitor to induce apoptosis in the mcf-7 and mrc-5 cell lines. mcf7 and mrc-5 cell lines were cultured in rpmi-1640 and treated with or without salermide...

osteonectin is a bone- associated protein involved in vascular calcification. adiponectin may protect against cardiovascular disease but possible effects on vascular calcification have been poorly studied. the aim of this study was to investigate the modulatory effect of adiponectin on oxidized low density lipoprotein (oxldl)- induced expression of osteonectin in human aorta vascular smooth mus...

BACKGROUND Urine protein detection could be underestimated using the conventional dipstick method because of variations in urine aliquots. This study aimed to assess the efficacy of the semi-quantitative urine protein-to-creatinine (P/C) ratio compared with other laboratory methods. METHODS Random urine samples were requested from patients undergoing chronic kidney disease screening. Signific...

In the present work, a quantum chemical study (Semi-empirical,PM6 method) is performed using nitrogen mustards (HN1, HN2 and HN3) as subjects in order to demonstrate that there is a close relationship between pharmacological activity and parameters such as formation enthalpy and number of conformers, which could, consequently, be employed as reliable QSAR descriptors. To the studied nitrogen mu...