Axon injury/loss, demyelination and inflammation are the primary pathologies in multiple sclerosis lesions. Despite the prevailing notion that axon/neuron loss is the substrate of clinical progression of multiple sclerosis, the roles that these individual pathological processes play in multiple sclerosis progression remain to be defined. An imaging modality capable to effectively detect, differ...

BACKGROUND AND PURPOSE Magnetization transfer imaging provides information about the structural integrity of macromolecular substances, such as myelin. Our objective was to use this imaging technique and contour plotting to characterize and to define the extent of white matter lesions in multiple sclerosis and traumatic brain injury. METHODS Magnetization transfer imaging was performed of 30 ...

BACKGROUND AND PURPOSE Our purpose was to compare diffusion tensor MR and magnetization transfer imaging in assessing normal-appearing white matter (WM) regions in multiple sclerosis (MS). METHODS Diffusion tensor, magnetization transfer, and conventional MR imaging were performed in 12 patients with MS. Fractional anisotropy, apparent diffusion coefficients (ADCs), and magnetization transfer...

Quantitative analysis of magnetization transfer images has the potential to allow a more thorough characterization of the protons, both bound and free, in a tissue by extracting a number of parameters relating to the NMR properties of the protons and their local environment. This work develops previously presented techniques to produce estimates of parameters such as the bound proton fraction, ...

The amide proton transfer (APT) effect has emerged as a unique endogenous molecular imaging contrast mechanism with great clinical potentials. However, in vivo quantitative mapping of APT using the conventional asymmetry analysis is difficult due to the confounding nuclear Overhauser effect (NOE) and the asymmetry of the magnetization transfer effect. Here, we showed that the asymmetry of magne...

in the current investigation, fe3o4 water-based nanofluids were synthesized to examine the effect of an alternative 3-d external magnetic field on its thermal behavioral pattern. a solvothermal method was used to prepare the magnetite nanoparticles. to characterize the nanoparticles, the study employed transmission electron microscopy, x-ray diffraction, fourier transform infrared spectroscopy,...

Introduction: Various mechanisms have recently been proposed to impact on the BOLD-contrast in steady-state sequences [1]. It has been speculated that magnetization transfer effects and/or relaxation during RF pulses, which are applied during a significant percentage of the imaging time, contribute to the detected signal changes. However, the investigation of various potential mechanisms has be...

OBJECTIVE We investigate how known differences in myelin architecture between regions along the cortico-spinal tract and frontal white matter (WM) in 19 healthy adolescents are reflected in several quantitative MRI parameters that have been proposed to non-invasively probe WM microstructure. In a clinically feasible scan time, both conventional imaging sequences as well as microstructural MRI p...