Human longevity is a complex phenotype influenced by genetic and environmental components. Unraveling the contribution of genetic vs. nongenetic factors to longevity is a challenging task. Here, we conducted a large-scale RNA-sequencing-based expression quantitative trait loci study (eQTL) with subsequent heritability analysis. The investigation was performed on blood samples from 244 individua...

While the machinery of quantitative genetics can blissfully function in complete ignorance of any of the underlying genetic details, we are certainly interested (at least one some level) on the genetic basis of trait variation. At the most practical level, if a gene of major effect is segregating in our population of interest, we would certainly like to not only to be aware of this, but also to...

We present a novel ensemble-based computational framework, EnsembleExpr, that achieved the best performance in the Fourth Critical Assessment of Genome Interpretation expression quantitative trait locus "(eQTL)-causal SNPs" challenge for identifying eQTLs and prioritizing their gene expression effects. eQTLs are genome sequence variants that result in gene expression changes and are thus prime ...

In an empirical Bayesian setting, we provide a new multiple testing method, useful when an additional covariate is available, that influences the probability of each null hypothesis being true. We measure the posterior significance of each test conditionally on the covariate and the data, leading to greater power. Using covariate-based prior information in an unsupervised fashion, we produce a ...

This article reviews key contributions in the area of statistics as applied to the use of molecular marker technology and quantitative genetics in the search for genes affecting quantitative traits responsible for specific diseases and economically important agronomic traits. Since an exhaustive literature review is not possible, the limited scope of this work is to encourage further statistica...

a simple, accurate and rapid high performance thin layer chromatography (hptlc)-densitometric method was developed for separation and determination of cetirizine (cet) as a long acting antihistamine and montelukast (mon) as an antileukotriene in pharmaceutical dosage forms. the compounds were separated on silica gel 60 f254 hptlc plates using a mixture of ethyl acetate : methanol : ammonia solu...

selecting an appropriate manufacturing machine is a very important and complex problem for firms, which usually have to deal with both qualitative and quantitative criteria. taking into account the differences among machines in terms of cost, speed, quality and after sale services, type and number of machines are important parameters to consider. therefore, the goal of this paper is to propose ...

Treating mRNA transcript abundances as quantitative traits and mapping gene expression quantitative trait loci for these traits has been studied in many species from yeast to humans. There has been significant success in finding associations between gene expression and genetic markers. These eQTL studies have been used to identify candidate causal regulators, to construct gene regulation networ...