Mutated KRAS promotes the activation of MAPK pathway and progression colorectal cancer (CRC) cells. Aberrant PI3K strongly attenuates efficacy suppression in KRAS-mutated CRC. The development a novel strategy targeting dual is therefore highly essential for therapy In this study, quadruple-depleting system KRAS, MEK1, PIK3CA, MTOR genes based on CRISPR/SaCas9 was developed. Adenovirus serotype ...

Membranous nephropathy is one of the most common causes nephrotic syndrome. Among available treatment options, tried and tested regimen modified Ponticelli regimen. Despite adequate therapy, studies have shown that close to one-quarter patients fail attain complete remission. However, data limited regarding who are resistant this

While pancreas transplantation has evolved within two decades from a frustrating and poorly-accepted therapeutic option to a highly successful procedure, the respective benefits of the successive surgical and immunosuppressive developments have remained unclear. The aim of this study was to determine using an evidence-based methodology, which novel approaches have contributed to the current res...

BackgroundQuadruple therapy is recommended for the management of patients with heart failure (HF) and reduced ejection fraction (HFrEF), however, many in Canada are not yet on triple therapy. In order to provide background identify barriers quadruple therapy, this study, aim was explore time initiate a population-based cohort de novo HF.Methods ResultsAdult hospital or emergency department diag...

background: gastric cancer is an important health problem across the world. chemotherapy in combination with local treatment is standard treatment for locally advanced gastroesophageal cancers. the purpose of this investigation was evaluation of response and tolerability to neoadjuvant eox regimen in locoregionally advanced gastric cancer. materials and methods: patients with locoregionally adv...