The classical least squares approach to parameter estimation for dynamic models ignores a priori information about the feasible values of the estimated parameters. But in many practical problems, such information is available in the form of upper and lower limits. In this paper, two alternative techniques are evaluated for this important class of constrained parameter estimation problems for dy...

Recent advances in structural biochemistry have provided evidence that not only the geometric properties but also the elastic moduli of duplex DNA are strongly dependent on nucleotide sequence in a way that is not accounted for by classical rod models of the Kirchhoff type. A theory of sequence-dependent DNA elasticity is employed here to calculate the dependence of the equilibrium configuratio...

Studies of neutron stars are at their peak after the multimessenger observation binary merger event GW170817, which strongly constrains stellar parameters like tidal deformability, masses, and radii. Although current future observations will provide stronger limits on parameters, knowledge explicit interior solutions to Einstein's equations, connect observed with internal structure, crucial hav...