To screen the quantitative trait loci (QTL) and genes related to growth of Yellow River carp (Cyprinus carpio haematopterus) after removing maternal effect, we established a family these carps. Four growth-related traits (body length, height, thickness, weight) at 5 17 months hatching (MAH) were measured. Analysis QTL mapping for four was conducted using genetic linkage map constructed in our l...

BACKGROUND Identification of QTL affecting a phenotype which is measured multiple times on the same experimental unit is not a trivial task because the repeated measures are not independent and in most cases show a trend in time. A complicating factor is that in most cases the mean increases non-linear with time as well as the variance. A two- step approach was used to analyze a simulated data ...

We develop and implement a strategy to map QTL in two synthetic populations of Drosophila melanogaster each initiated with eight inbred founder strains. These recombinant populations allow simultaneous estimates of QTL location, effect, and frequency. Five X-linked QTL influencing bristle number were resolved to intervals of approximately 1.3 cM. We confirm previous observations of bristle numb...

Pursuing fully a suggestion from linkage analysis that there might be a quantitative trait locus (QTL) for blood pressure (BP) in a chromosome (Chr) 2 region of the Dahl salt-sensitive rat (DSS), four congenic strains were made by replacing various fragments of DSS Chr 2 with those of Lewis (LEW). Consequently, a BP QTL was localized to a segment of around 3 cM or near 3 Mb on Chr 2 by comparat...

Maximum likelihood methodology was used to estimate effects of both a marker gene and a linked quantitative trait locus (QTL) on quantitative traits in a segregating population. Two alleles were assumed for the QTL. In addition to the effects of genotypes at both loci on the mean of the quantitative trait, recombination frequency between the loci, frequency of the QTL alleles and the residual s...

The proportion of alleles identical by descent (IBD) determines the genetic covariance between relatives, and thus is crucial in estimating genetic variances of quantitative trait loci (QTL). However, IBD proportions at QTL are unobservable and must be inferred from marker information. The conventional method of QTL variance analysis maximizes the likelihood function by replacing the missing IB...

Abstract Phenotypes of sessile organisms, such as plants, rely not only on their own genotypes but also those neighboring individuals. Previously, we incorporated neighbor effects into a single-marker regression using the Ising model ferromagnetism. However, little is known regarding how should be in quantitative trait locus (QTL) mapping. In this study, propose new method for interval QTL mapp...

An F(2) population (695 individuals) was established from broiler chickens divergently selected for either high (HG) or low (LG) growth, and used to localize QTL for developmental changes in body weight (BW), shank length (SL9) and shank diameter (SD9) at 9 weeks. QTL mapping revealed three genome-wide QTL on chromosomes (GGA) 2, 4 and 26 and three suggestive QTL on GGA 1, 3 and 5. Most of the ...

For many species several similar QTL mapping populations have been produced and analyzed independently. Joint analysis of such data could be used to increase power to detect QTL and evaluate population differences. In this study, data were collated on almost 3000 pigs from seven different F(2) crosses between Western commercial breeds and either the European wild boar or the Chinese Meishan bre...

Fifty-five microsatellite markers were scored in an F2 population of pigs (n = 114 females) developed at the University of Nebraska. The population was produced by crossing a line previously selected for 10 generations using an index of ovulation rate and embryonal survival and a line selected at random. The lines were from a common base population and differed by 6.7 ovulations and 3.1 fetuses...