BACKGROUND Inadequate designs and conflicting results from previous studies prompted the US Food and Drug Administration to publish guidelines for the design of clinical trials evaluating the effects of orally inhaled and intranasal corticosteroids on the growth of children. This study conformed to these guidelines to evaluate the effect of triamcinolone acetonide aqueous nasal spray (TAA-AQ) o...

Let f ∈ L2(S2) be an arbitrary fixed function on the unit sphere S2, and D ⊂R3 be an arbitrary fixed bounded domain. Let k > 0 and α ∈ S2 be fixed. It is proved that there exists a potential q ∈ L2(D) such that the corresponding scattering amplitude A(α′) = Aq(α′) = Aq(α′, α, k) approximates f (α′) with arbitrary high accuracy: ‖f (α′)−Aq(α′)L2(S2)‖ ε where ε > 0 is an arbitrarily small fixed n...

Malaria remains the leading burden of disease in post-conflict Sierra Leone. To overcome the challenge of anti-malarial drug resistance and improve effective treatment, Sierra Leone adopted artemisinin-combination therapy artesunate-amodiaquine (AS+AQ) as first-line treatment for uncomplicated P. falciparum malaria. Other national policy anti-malarials include artemether-lumefantrine (AL) as an...

It has been demonstrated that continuous exposure to amodiaquine (AQ) alone elicits in vitro antischistosomal activities at concentrations of 1-10 μg/ml. However, orally administered drugs reach a peak blood concentration within one or two hours and then gradually decrease. The blood concentration does not remain at a constant level over several days as in vitro concentration of continuous drug...

The aggregation numbers, NA, of normal sodium alkyl sulfate micelles were measured by time-resolved fluorescence quenching in order to test two aspects of a recent proposal by Quina et al. (J. Phys. Chem. 1995, 99, 17028) that these micelles grow as a power law of the total counterion concentration, [Na]aq, in the aqueous phase according to NA ) κ2([Na]aq), where κ2 and γ are constants for a gi...

We examine the role of target firms’ accruals quality (AQ) on the course of the acquisition process. We predict and find that target AQ is significantly associated with the choice of sales method (auction vs. negotiation), acquirer and target returns, the likelihood of deal completion, and the speed of the process overall. We further find that AQ has a more pronounced effect on M&A transactions...

Resistance of Plasmodium falciparum (Pf) and P. vivax (Pv) to standard antimalarials is widespread in Papua New Guinea (PNG). The objective of the study was to assess the rate of clinical treatment failure (TF) and parasite resistance to amodiaquine (AQ), chloroquine (CQ) and quinine+sulfadoxine/pyrimethamine (Q+SP) for malaria in a rural health centre of the East Sepik Province. 179 patients p...

Sea cucumbers have been a dietary delicacy and important ingredient in Asian traditional medicinal over many centuries. In this study, edible sea cucumber Holothuria edulis was evaluated for its in vitro anticancer potential. An aqueous fraction of the edible sea cucumber (ESC-AQ) has been shown to deliver a strong cytotoxic effect against the human HL-60 leukaemia cell line. An induction effec...

Scores on the autism spectrum quotient (AQ) were examined in 65 adults with ASD. Maternal reports of symptoms were collected simultaneously using the autism diagnostic interview-revised (ADI-R) and the Vineland Screener. A slightly revised AQ administration procedure was used to accommodate adults with below average IQ. AQ scores were lower than in the original validation study, with only 11 ad...

In the synthesis of the disordered lyotropic liquid crystalline L3 sponge phase prepared with the cosurfactants cetylpyridinium chloride and hexanol, aqueous NaCl solution is used as the solvent. When this sponge phase is used as the template for L3 silica-phase processing, we replace NaCl with HCl to facilitate the acid catalysis of tetramethoxysilane in forming a templated silica gel, assumin...