In the title compound, C(20)H(18)N(2)O, the pyrazole ring adopts a planar conformation. The C-N bond lengths in the pyrazole ring are shorter than a standard C-N single bond (1.443 Å), but longer than a standard double bond (1.269 Å), indicating electron delocalization. The propenal group assumes an extended conformation. Inter-molecular C-H⋯O hydrogen bonds connect mol-ecules into cyclic centr...

Pyrazole-containing compounds represent one of the most influential families N-heterocycles due to their proven applicability and versatility as synthetic intermediates in preparing relevant chemicals biological, physical-chemical, material science, industrial fields. Therefore, synthesizing structurally diverse pyrazole derivatives is highly desirable, various researchers continue focus on thi...

PURPOSE To synthesize a new series of 5-substituted-3-methylsulfanyl-1H-pyrazole-4-carboxylic acid ethyl esters for their analgesic and anti-inflammatory activity. METHODS The title compound synthesized by reacting the amino group of 5-amino-3-methylsulfanyl-1H-pyrazole-4-carboxylic acid ethyl ester with acid anhydrides, acid chlorides and phenyl dithiocarbamates. The synthesized compounds we...

The title compound, C(9)H(12)N(4)O(4)S, was proven to be the product of the reaction of methyl 5-amino-1H-pyrazole-3-carboxyl-ate with ethyl isothio-cyanato-carbonate. All non-H atoms of the mol-ecule are planar, the mean deviation from the least squares plane being 0.048 Å. The intra-molecular N-H⋯O bond involving the NH-group, which links the thio-urea and pyrazole fragments, closes a six-mem...

In the title pyrazole compound, C(22)H(17)N(3)O(4), an intra-molecular C-H⋯O contact generates a seven-membered ring, producing an S(7) ring motif. The furan and pyrazole rings are essentially planar [maximum deviations = 0.004 (1) and 0.004 (2) Å, respectively] and are almost coplanar, making a dihedral angle of 3.75 (10)°. One of the methyl-phenyl groups is inclined to the pyrazole ring, as i...

Microdochium patch is a destructive disease of amenity turfgrass caused by the fungus nivale (Fries) Samuels & I.C. Hallett. The succinate dehydrogenase (SDHI) class fungicides relatively new and their efficacy against M. remains unclear. Fluxapyroxad (3-(difluoromethyl)-1-methyl-N-[2-(3,4,5-trifluorophenyl)phenyl]pyrazole-4-carboxamide), penthiopyrad (1-methyl-N-[2-(4-methylpentan-2-yl)thiophe...

A series of heteroleptic Ir(III) metal complexes 1-3 bearing two N-phenyl-substituted pyrazoles and one 2-pyridyl pyrazole (or triazole) ligands were synthesized and characterized to attain highly efficient, room-temperature blue phosphorescence. The N-phenylpyrazole ligands, dfpzH = 1-(2,4-difluorophenyl)pyrazole, fpzH = 1-(4-fluorophenyl)pyrazole, dfmpzH = 1-(2,4-difluorophenyl)-3,5-dimethylp...

S-adenosyl-L-methionine (SAMe) is protective against a variety of hepatotoxins, including ethanol. The ability of SAMe to protect against cytochrome P-450 2E1 (CYP2E1)-dependent toxicity was studied in hepatocytes from pyrazole-treated rats and HepG2 E47 cells, both of which actively express CYP2E1. Toxicity was initiated by the addition of arachidonic acid (AA) or by depletion of glutathione a...