710 started an oral ibrutinib therapy (3 × 140 mg/d), due to B-CLL. An ulcer biopsy revealed lymphocyte and neutrophil infiltration. No histopathologic signs of carcinoma or vasculitis were observed. After consultation with a hematologist, a tentative diagnosis of ibrutinib-induced pyoderma gangrenosum (PG) was established. In addition to ibrutinib discontinuation, daily prednisone dose was inc...

Superficial granulomatous pyoderma (SGP) or pyoderma vegetans is a rare inflammatory disease first described by Wilson-Jones and Winkelmann in 1988. Although considered a superficial, vegetative variant of pyoderma gangrenosum (PG), SGP has distinguishing features such as a chronic and slowly progressive course, lack of association with other diseases, shallower ulcers, the presence on histolog...

Pyoderma gangrenosum (PG) is a rare entity belonging to the neutrophilic dermatoses. It an inflammatory dermatosis with chronic evolution by relapses, often revealing associated underlying disease. The location breast represents unusual, poorly documented in literature and whose diagnosis remains difficult establish.

IL: interleukin PG: pyoderma gangrenosum TA: Takayasu arteritis INTRODUCTION Pyoderma gangrenosum (PG) is a type of neutrophilic dermatosis that shows noninfectious ulcers characterized by neutrophil infiltration of the skin. PG is frequently associatedwith systemic diseases such as inflammatory bowel disease, rheumatoid arthritis, and hematologic disorders. In Japan, PG is also awellknown comp...

Pyoderma gangrenosum is a very rare, non-infectious leukocytic dermatosis, which is often associated with an underlying systemic disease. It is usually diagnosed based on the apparent clinical findings and by excluding other causes of ulcerative skin diseases. Treatment modality includes the use of systemic steroids and oral steroids. Immunosuppressive agents, such as cyclosporine and mycopheno...