The incidence and determinants of severe morbidity recurrence in sub-Saharan African HIV-infected adults on antiretroviral therapy (ART) have never been reported. In a prospective cohort study of HIV-infected adults in Abidjan the association of severe morbidity occurrence and recurrence with follow-up CD4 counts and ART on/off status was analyzed by means of multivariate failure analysis for r...

The property that describes the neuron's preferred response to inputs of injected current is called resonance. To produce resonance, a cell must have two requirements: a low-pass filter (attenuates high frequencies) and a high-pass filter (attenuates low frequencies). The neuron whose resonance frequency we wish to determine is the PY neuron of the STNS (stomatogastric nervous system) of Cancer...

The aim of this study was to test the genotypes effect of DGAT1 gene on breeding value in Iranian Holstein milk production traits. For this purpose, 103 semen samples of registered bulls were collected and then genotyped for partial region of DGAT1 gene. The studied traits were milk yield (MY), fat yield (FY), protein yield (PY), fat percentage (FP) and protein percentage (PP). First lactation ...

BACKGROUND The suitability of populations of sexually active women in Madibeng (North-West Province) and Mbekweni (Western Cape), South Africa, for a Phase III vaginal microbicide trial was evaluated. METHODS Sexually active women 18-35 years not known to be HIV-positive or pregnant were tested cross-sectionally to determine HIV and pregnancy prevalence (798 in Madibeng and 800 in Mbekweni). ...

BACKGROUND Female sex workers in Australia have achieved some of the lowest documented prevalences of human immunodeficiency virus (HIV) and other sexually transmissible infections globally but rates overall are increasing in Australia and warrant closer investigation. METHODS We constructed a retrospective cohort using repeat testing data extracted from a network of 42 sexual health clinics....

BACKGROUND  Conflicting data exist with regard to recurrence rates of intestinal metaplasia (IM) and dysplasia after achieving complete eradication of intestinal metaplasia (CE-IM) in Barrett's esophagus (BE) patients. AIM  (i) To determine the incidence of recurrent IM and dysplasia achieving CE-IM and (ii) to compare recurrence rates between treatment modalities [radiofrequency ablation (RF...

The pharmacokinetic properties of three pyrrole-imidazole (Py-Im) polyamides of similar size and Py-Im content but different shape were studied in the mouse. Remarkably, hairpin and cyclic oligomers programmed for the same DNA sequence 5'-WGGWWW-3' displayed distinct pharmacokinetic properties. Furthermore, the hairpin 1 and cycle 2 exhibited vastly different animal toxicities. These data provi...

A mononuclear complex [MoOCl4(H2O)] readily forms a metal−metal bonded {Mo2O4} core. A high content of pyridine in the reaction mixture prevents further aggregation of dinuclear cores into larger clusters and a neutral, dinuclear complex with the [Mo2O4Cl2(Py)4] composition is isolated as a product. Solid state structures of two compounds containing this complex, [Mo2O4Cl2(Py)4]·2.25Py (1) and ...

A furan amino acid, inspired by the recently discovered proximicin natural products, was incorporated into the scaffold of a DNA-binding hairpin polyamide. While unpaired oligomers of 2,4-disubstituted furan amino acids show poor DNA-binding activity, furan (Fn) carboxamides paired with N-methylpyrrole (Py) and N-methylimidazole (Im) rings demonstrate excellent stabilization of duplex DNA as we...