3 Acknowledgments 4 Table of

EPPO have since 1987 had an activity on creating guidelines for Good Plant Protection Practise with the overall aim of helping to minimze the risk from using pesticides. This has so fare lead to the creation of 18 specific guidelines on crops of major importance in the EPPO region. The wish is that these guidelines should be used to guide national authorities and advisory services on questions ...

Vegetation light use efficiency (LUE) is a key parameter of Production Efficiency Models (PEMs) for simulating gross primary production (GPP) of vegetation, from regional to global scales. Previous studies suggest that grasslands have the largest inter-site variation of LUE and controlling factors of grassland LUE differ from those of other biomes, since grasslands are usually water-limited eco...

Present medical practice encourages management according to written guidelines, protocols, and structured procedures (GPPs). Daily medical practice includes instances in which "leaping" from one patient management routine to another is a must. We define "frozen patient management", when patient management leaping was required but was not performed. Frozen patient management may cause significan...

In Effisayil 1 (NCT03782792), the safety and efficacy of spesolimab was assessed in patients with a GPP flare. Patients (N=53) were randomised (2:1) to intravenous 900 mg or placebo on Day followed for 12 weeks. The primary key secondary endpoints Generalized Pustular Psoriasis Physician Global Assessment (GPPGA) pustulation subscore 0 GPPGA total score at Week 1, respectively. We explore basel...

BACKGROUND Dysregulation of angiogenesis and lymphangiogenesis could participate in psoriasis pathogenesis. Analysis of nascent psoriasis lesions should help at identifying early vascular anomalies. OBJECTIVE To analyse vascular development, angiogenesis and lymphangiogenesis markers expression in uninvolved skin in psoriatic patients (N), early psoriasis lesions or pinpoints (PP) and psorias...

Lithium is known to cause a variety of dermatological problems, common ones being acneiform eruptions, folliculitis and psoriasis including its pustular form. Hidradenitis suppurativa and acne conglobata are lesser known side effects, with only three reports so far. We report a patient, who had bipolar affective disorder, was on lithium for a long duration and developed hidradenitis suppurativa...

G eneralized pustular psoriasis (GPP), von Zumbusch type, is an uncommon variant of psoriasis characterized by acute-onset severe inflammation and widespread sterile pustules within psoriatic plaques. GPP is a medical emergency that often requires hospitalization because of possible life-threatening complications, including heart failure, renal failure, and sepsis. Existing treatment options fo...

Introduction Loss-of-function mutations in the IL36RN gene define a novel recessively inherited autoinflammatory syndrome named deficiency of IL-36 receptor antagonist (DITRA). This genetically determined deficiency was first described in a subgroup of patients with generalized pustular psoriasis. It is a life-threatening condition characterized by recurrent episodes of severe skin inflammation...