Up to now studies on hypothalamic-pituitary-adrenal (HPA) axis activity in psychosis have shown inconsistent findings. These inconsistencies have been often ascribed to confounding effects of long duration of illness and chronic treatment with psychotropic medications of the subjects studied (chronic psychosis). In the last years, several studies have focused on the study of subjects at their f...

This is an exploratory paper of the ethical implications for genomic research and mental illness with specific reference to Singapore. Singapore has a unique context due to its social and political systems, and although it is a relatively small country, its population is religiously and culturally diverse. The issues that we identify here, therefore, will offer new perspectives and will also sh...

MAIN RESULTS Prognosis: Women with a history of psychosis are at high risk of a psychiatric episode in the first year after childbirth (see table). Psychosis as a risk factor for post-natal depression: Women with a history of psychosis are more likely to have postnatal depression compared with age matched controls in the first year after childbirth (RR adjusted for active illness 2.04, 95% CI 1...

OBJECTIVE Recent research has shown high rates of exposure to trauma among people with serious mental illness (SMI). In addition, studies suggest that psychosis and mental illness-related experiences can be extremely traumatic. While some individuals develop full blown PTSD related to these experiences, it has been noted that some may also experience posttraumatic growth (PTG). However, few stu...

BACKGROUND Neurological soft signs preceding adult-onset schizophrenia suggest a neurodevelopmental origin and could reflect physical illness in childhood. AIMS To investigate possible associations of adult-onset psychosis with neurological soft signs and common infectious illnesses in childhood. METHOD Using data from the UK National Child Development Study, a longitudinal general populati...