In the letter by Scorza and Cavalheiro1, the authors posit that the use of psychoanalysis for neuropsychiatric syndromes “has a direct positive influence” on neurogenesis. Yet, the authors acknowledge that the putative mechanisms to explain the alleged role of psychoanalysis on neuroplasticity remain “still poorly explored”. In a letter addressed to Wilhelm Fliess in April 1895, Sigmund Freud m...