نتایج جستجو برای: psoriasis
تعداد نتایج: 17624 فیلتر نتایج به سال:
Lithium has been implicated in the exacerbation of pre-existing psoriasis, in the induction of psoriasis on previously uninvolved skin of psoriasis patients, and in the triggering of psoriasis for the first time in patients without a personal or family history. Lithium-induced psoriasis (and its resistance to treatment) is one of the major reasons for noncompliance in patients treated with lith...
Psoriasis can involve the skin, joints, and nails, either alone or in combination. Psoriasis of the nails can involve both the nail bed and nail matrix. The treatment of nail psoriasis largely depends on the severity of symptoms. The pulsed dye laser (PDL) recently has demonstrated efficacy in treating resistant plaque-type psoriasis and has been suggested as an alternative to conventional ther...
Psoriasis is a chronic inflammatory skin disease affecting approximately 2% of the population worldwide. In the past decade, many studies have drawn attention to comorbid conditions in psoriasis. This literature review examines the epidemiological evidence, pathophysiological commonalities, and therapeutic implications for different comorbidities of psoriasis. Cardiovascular disease, obesity, d...
Introduction Familial Mediterranean fever (FMF) is an autosomal recessive disease characterized by periodic fever and polyserositis attacks. FMF can be associated with vasculitis, spondyloarthropaties, Behçet’s disease and inflammatory bowel disease. Psoriasis is another disease that can be associated with FMF. Psoriasis is a common disease affecting approximately 2% of the population. Although...
BACKGROUND Human tissue kallikreins (KLKs) are a family of 15 trypsin-like or chymotrypsin-like secreted serine proteases (KLK1-KLK15). Multiple KLKs have been quantitatively identified in normal stratum corneum (SC) and sweat as candidate desquamation-related proteases. OBJECTIVES To quantify KLK5, KLK6, KLK7, KLK8, KLK10, KLK11, KLK13 and KLK14 in the SC and serum of patients with psoriasis...
Psoriasis, which presents as red, scaly patches on the body, is a common, autoimmune skin disease that affects 2 to 3 percent of the world population. To leverage recent molecular findings into the personalized treatment of psoriasis, we need a strategy that integrates clinical stratification with molecular phenotyping. In this study, we sought to stratify psoriasis patients by histological mea...
BACKGROUND Genes encoded within the MHC complex on chromosome 6 are thought to play an important role in the pathogenesis of psoriasis. A potential candidate is tumor necrosis factor alpha (TNF-alpha) gene. Psoriasis features an increased activity of the proinflammatory cytokine TNF-alpha in affected lesions. TNF-alpha promoter region contains several polymorphisms, including G/A transition at ...
Psoriasis has been linked to cardiometabolic diseases, but epidemiological findings are inconsistent. We investigated the association between psoriasis and cardiometabolic outcomes in a German cross-sectional study (n=4,185) and a prospective cohort of German Health Insurance beneficiaries (n=1,811,098). A potential genetic overlap was explored using genome-wide data from >22,000 coronary arter...
BACKGROUND A number of studies have suggested an increased frequency of cardiovascular (CV) diseases in patients with psoriasis. OBJECTIVE In this study, we assessed the awareness among psoriasis patients and dermatologists in private primary clinics about the increased CV risk linked to psoriasis, and examined the screening behaviors of dermatologists for CV risk factors in psoriasis patient...
Psoriasis is a chronic skin disease associated with problems in body image and self-esteem and feelings of stigma and shame. The aim of this study was to analyse the clinical extent of psoriasis and its association with psychological distress, and to compare the psychopathological traits in early-onset (type I: age of onset < 40 years) vs. late-onset (type II: age of onset > 40 years) psoriasis...
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