BACKGROUND In the AFFIRM trial, enzalutamide significantly increased overall survival (OS) for men with metastatic castration-resistant prostate cancer (mCRPC) after chemotherapy versus placebo and significantly decreased prostate-specific antigen (PSA) levels. The goal of this post hoc analysis was to associate levels of PSA decline from baseline after enzalutamide with clinical outcomes in th...

BACKGROUND The aim of our study was to identify the optimal predictor of prostate cancer among several prostate-specific antigen (PSA) derivatives in repeat prostate biopsy. METHODS We retrospectively assessed the repeat prostate biopsy specimens, obtained between 1999 and 2008, of 212 patients with a total PSA (tPSA) of 4-10 ng/ml and normal digital rectal examination. Using a receiver opera...

Bordetellosis, caused by Bordetella avium infection, is characterized by tracheal inflammation, epithelial cell degeneration, and tracheal distortion. The inflammation results from dermonecrotic toxins produced by B. avium. Inflammatory reactions are accompanied by generation of reactive oxygen metabolites (ROM) that kill cells. Antioxidant enzyme activity associated with either sodium selenite...

C-reactive protein (CRP) is an inflammatory protein released by the body in response to infection and injury. Elevation of this serum protein has been linked to increased risks of heart disease through inflammation that is believed to play a key role in the hardening of arteries resulting in a heart attack or stroke. Consequently, CRP could serve as a genetic marker for an eminent cardiac event...

Broiler starter diets from three commercial feed mills (same company, different locations) were fed to day-old Hubbard Hi-Y broiler chicks along with a Control diet manufactured at Ohio State University. The analyzed calcium levels were as follows: Source 1, .76% ; Source 2, .97% ; Source 3, .81 % ; Control, .98%. Each of the diets was fed to 5 replicate pens of broiler chicks in Petersime batt...

PURPOSE We evaluated predictors of prostate cancer-specific mortality (PCSM) after prostate-specific antigen (PSA) failure after radical prostatectomy (RP) or radiation therapy (RT). PATIENTS AND METHODS A total of 1,159 men with clinically localized prostate cancer treated with RP (n = 498) or RT (n = 661) developed PSA failure, and they formed the study cohort. Competing risk regression ana...

BACKGROUND The objective of this study is to explore the impact of PSA nadirs on detection rates of prostate cancer (PCa) recurrence with 18F-choline (CH) PET/CT after external beam radiation therapy (EBRT). METHODS In this retrospective study, data were collected from 54 patients with suspicion of PCa biochemical recurrence after EBRT (28 patients treated initially with EBRT and 26 as salvag...

We studied predictors for the progression of incidental prostate cancer (PCa) to optimize the management strategies that are still controversial in the era of prostate-specific antigen (PSA). We performed advanced transurethral resection of the prostate (TURP) in 995 patients with benign prostate hyperplasia (BPH). Of these, 226 patients (22.7%) had incidental PCa. Included in the present study...

BACKGROUND The nature of free, uncomplexed prostate-specific antigen (PSA) in the circulation is still unknown. In this study, we developed novel anti-PSA antibodies using PSA produced by a metastasized cancer cell line, LNCaP, as an immunogen. METHODS Hybridoma cell lines were screened with different methods that aimed at finding antibodies specific for the forms of free PSA produced by LNCa...