Hydrogen sulphide (H2S), a newly identified gasotransmitter, can be endogenously produced by cystathionine gamma-lyase (CSE) in the cardiovascular system. This study investigated role of CSE/H2S system on lipid overload-induced lipotoxicity and cardiac senescence. Lipid overload rat cardiomyocyte cells (H9C2) promoted intracellular accumulation lipid, oxidative stress, mitochondrial dysfunction...

Membranes do not only provide a matrix for variety of chemical reactions mediated by membrane proteins, but also actively participate in the regulation protein structure and function. We conducted molecular dynamics simulations to investigate how lipid-protein interactions affect function case MthK, potassium channel. constructed different bilayers test effects thickness, cholesterol content, u...