objective(s):this study examined whether conjugated linoleic acid (cla) supplementation affects insulin sensitivity and peroxisome proliferator-activated receptor gamma (ppar-γ) and glucose transporter type 4 (glut-4) protein expressions in the skeletal muscles of rats during endurance exercise. materials and methods:sprague-dawley male rats were randomly divided into hs (high-fat diet (hfd) se...

Insulin-like growth factor 1 (IGF-1) is a polypeptide hormone produced mainly by the liver in response to the endocrine growth hormone (GH) stimulus. This protein is involved in a wide range of cellular functions, including cellular differentiation, transformation, apoptosis suppression, migration and cell-cycle progression and other metabolic processes. In the current study, human heart cDNA w...

Background MIF via its receptor, CD74, initiates a signaling cascade that leads to proliferation and survival of cells. Also, MIF binding to CD74 activates p38 signaling pathways that lead to positive effect on the expression of COX-2. The aim of this study was to evaluate the gene expression profile of MIF, CD74 and COX-2 in normal, ectopic and eutopic endometrium during menstrual cycle. The e...

an experiment was carried out to evaluate how interactions between forage to concentrate ratio and dietary crude protein level may alter nitrogen efficiency and ut-b expression in growing baluchi male lambs. four baluchi male lambs [30 ± 2 kg bw] were used in a 4 × 4 latin square design with 28-d periods and a 2 × 2 factorial arrangement of dietary treatments. the treatments fed forage: concent...

the effects of drought stress and exogenous abscisic acid on the expression of ribulose-1, 5-bisphosphate carboxyiase/oxygenase activase (rubisco activase) were examined in wheat (triticum aestivuml.). in response to water stress and abscisic acid, both the levels of endogenous abscisic acid and rubiscoactivase increased in the leaves. immunoblot analysis showed that both drought stress and abs...

introduction : designing an effective vaccine against human immunodeficiency virus (hiv)-1 is a global health priority . multi-epitope vaccines offer several potential advantages that may be promising in case of mutable divergent pathogens such as hiv-1. herein, a multiepitopic recombinant protein containing various hiv-1 antigens was expressed in e. coli cells and its immunogenicity in combina...

background: vascular endothelial growth factor (vegf) is a coordinate regulator of physiological angiogenesis during embryogenesis, skeletal growth and reproductive functions. there are several types of vegf, including vegf165. vegfs stimulate endothelial cell growth, angiogenesis, and capillary permeability. low induction temperature is a major factor for expression of the recombinant vegf165 ...

background: bone morphogenetic proteins (bmps) belong to the transforming growth factor-β (tgf-β) superfamily, and play an important role in bone metabolism. recombinant forms of bmp-2 and bmp-7 are the only bmps used clinically. in this study the mature part of human bone morphogenetic protein-7 (bmp-7) was engineered through substitution of the bmp-7 n-terminal sequence by heparin-binding sit...