Background: Protein C (PC) deficiency has been reported in sickle cell disease (SCD) and postulated to contribute to the pathogenesis as well as clinical manifestations of SCD. However there is paucity of data on PC in Nigerian patients with SCD. Objectives: This study was aimed at evaluating the levels of Protein C (PC) antigen and activity in SCD subjects; the prevalent type of PC deficiency ...

UNLABELLED Inherited thrombophilia can be defined as a predisposition to thrombosis caused by heritable defects, such as mutations in genes encoding the natural anticoagulants or clotting factors. Pregnancy related risk of VTE is sixfold increased comparing to non pregnant age matched women. Pregnancy is an independent risk factor for the development of venous thromboembolism and this risk is f...

Unfavorable weather conditions and lack of appropriate farm machinery often delay N application. This results in nitrogen (N) deficiency during the vegetative early reproductive growth stages winter wheat. The objective this study was to evaluate impact application timings (from tillering flag leaf stages) on wheat grain yield protein. conducted across 12 site–years Oklahoma, US. treatments inc...

Severely low-protein (LP) diets induce a decrease in body weight and an increase relative food including intake (FI) rat. In the liver, changes anabolic catabolic protein pathways could transitorily participate to compensate for amino acid (AA) deficiency. The present study investigated these liver muscle metabolic on LP diet fed growing rats. Growing rats were three weeks different containing ...

A family with a history of recurring thrombosis was studied to determine if a plasma protein deficiency could account for the observed disease. Protein C levels in plasma were determined immunologically using the Laurell rocket technique. The propositus, his father, and his paternal uncle, who are severely affected, had 38-49% of normal levels of protein C antigen, whereas unaffected family mem...

Introduction: Megaloblasc anemia is an uncommon problem in childhood most frequently associated with vitamin deficiency or gastrointesnal disease. The common causes of megaloblasc anemia are vitamin B12 (cobalamin) deficiency and folic acid deficiency. Familial selecve malabsorpon of vitamin B12 associated with proteinuria firstly was described by Imerslund (1960) and Grasbeck et al (1960)...

BACKGROUND Arterial ischemic stroke (AIS) and sinovenous thrombosis (SVT) are relatively rare events in children. The contribution of prethrombotic disorders to the etiology of these entities has not been completely elucidated. OBJECTIVES To determine the frequency of inherited and acquired prethrombotic disorders in a pediatric population with AIS and SVT and to report clinical and radiologi...

Protein Z (PZ) is a plasma vitamin K-dependent protein that functions as a cofactor to dramatically enhance the inhibition of coagulation factor Xa by the serpin, protein Z-dependent protease inhibitor (ZPI). In vitro, ZPI not only inhibits factor Xa in a calcium ion-, phospholipid-, and PZ-dependent fashion, but also directly inhibits coagulation factor XIa. In murine gene-deletion models, PZ ...