Vascular access thrombosis is one of the major causes of morbidity in patients maintained on chronic hemodialysis. Thrombophilia has been recognized as a risk factor of vascular access thrombosis. The authors report a case of inherited protein S deficiency associated with vascular access thrombotic events. DNA sequence analysis of the PROS1 gene identified a novel heterozygous nonsense mutation...

Protein S deficiency (PSD) has been the most difficult to study among the classical inherited thrombophilic factors. This is in part due to the peculiar biology of protein S (PS), which has an anticoagulant role but no enzymatic activity, and because it interacts with plasma components that function in both haemostasis and inflammation. Clinically, it also has been difficult to define and stand...

References 1. Levine SR, Welch KMA: Cerebrovascular ischemia associated with lupus anticoagulant. Stroke 1987; 18:257-263 2. Levine SR, Welch KMA: The spectrum of neurological disease associated with antiphospholipid antibodies: Lupus anticoagulants and anticardiolipin antibodies. Arch Neurol 1987;44: 876-883 3. Levine SR, Welch KMA: Antiphospholipid antibodies. Ann Neurol 1989;26:386-389 4. Ya...

The coronavirus disease 2019 (COVID-19) or severe acute respiratory syndrome 2 (SARS-CoV-2) pandemic has affected different communities all over the world. A wide spectrum of complications been reported due to COVID-19 infection, among which a hypercoagulability state is one most significant. patient was 44-year-old obese woman with history diabetes, hypothyroidism, cigarette smoking and opium ...

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To the Editor: We have read with special attention the letter of Davous et al. Because the association between hereditary protein S deficiency and cerebral arterial thrombosis is controversial,' we are reporting another case with this same association in which other members of the family were affected by arterial thrombotic diseases. A 44-year-old man was admitted to our hospital a few hours af...

Protein S (PS) is an extensively studied protein with an important function in the down-regulation of thrombin generation. Because of the presence of a pseudogene and two different forms of PS in plasma, a bound and a free form, it is one of the most difficult thrombophilias to study. A deficiency of PS predisposes subjects to (recurrent) venous thromboembolism (VTE) and foetal loss. However, t...

We report a case of a 6-year-old girl with severe protein S deficiency due to a homozygous mutation and recurrent episodes of skin necrosis. She developed purpura fulminans at birth and a catheter-related venous thrombosis complicated by massive pulmonary embolism at the sixth day of life. Long-term oral anticoagulant therapy with a vitamin K-antagonist was started with a therapeutic range of t...

Pregnancy is a hypercoagulable state associated with an increased risk of venous thromboembolic disease (VTE). We retrospectively studied 38 Caucasian pregnant women with thrombophilia risk and compared their obstetric outcomes with a matched cohort without known thrombophilia risk during the period between January 2007 and December 2010. There were (2) cases with factor V Leiden, (6) prothromb...