objective(s) staphylococcus aureus is a leading cause of many nosocomial and community acquired infections. according to many reports, antibiotic therapy can not guarantee the eradication of s. aureus infections. thus designing an adhesin based vaccine could restrain the s. aureus infections. this study designed for construction of a new fusion protein vaccine against s. aureus infections based...

Introduction: Bone pain palliation therapy is a mandate in handling end-stage cancer patients. The development of new ligands with higher stability, better pharmacokinetics and lower unwanted tissue uptakes (liver and GI) is still ongoing. Methods: In this work Lu-177 labeled (3-amino-1-hydroxypropane-1,1-di-yl)-bis-(phosphonate) (177Lu-pamidronate; 177Lu-PAM ), ...

one of the most important targets in alzheimer disease is beta site amyloid precursor protein cleaving enzyme-1 (bace-1). it is a membrane associated protein and is one of the main enzymes responsible for amyloid β (aβ) production. up to now, a considerable number of peptidic and non-peptidic inhibitors of bace-1 have been developed. recently, small molecule bace-1 inhibitors have attracted the...

background: bacterial superantigen staphylococcal enterotoxins (ses), has stimulated polyclonal t cells irrespective of their antigen specificity, resulted a massive release of cytokines, and suggested that they could be assigned as a candidate of new antitumor agents. recent attempts have done to specifically target superantigens towards tumors, subsequently monoclonal antibodies and tumor-rel...

Abstract The acidic activation domain (AD) of yeast transcription factor Gal4 plays a dual role in repression and through binding to Gal80 repressor Mediator subunit Med15. function arises from two hydrophobic regions within the 40-residue AD. We show by NMR that each AD region binds Med15 using “fuzzy” protein interface. Remarkably, comparison chemical shift perturbations shows Gcn4, intrinsic...

Nucleic acid-based biosensors for the detection of specific proteins combine typical programmability synthetic DNA systems with artificially controlled DNA-protein communication. The high-affinity interaction between a target protein and ligand, such as an aptamer sequence, or double stranded domain, small peptide, is paired nature-mimicking molecular mechanism allowing probing, processing, tra...

SARS-CoV-2 remains life-threatening human pathogen witnessed in the present world. Purpose. The key objective of this research was to incorporate a bioinformatics technique forecast molecular docking ACE2-associated SARS-CoVs nucleocapsid protein. Methods. Different tools were used study order compare chemical structures with their biological behaviour at levels atoms and ligand-binding affinit...