Protected areas remain a cornerstone for global conservation. However, their effectiveness at halting biodiversity decline is not fully understood. Studies of protected area benefits have largely focused on measuring their impact on halting deforestation and have neglected to measure the impacts of protected areas on other threats. Evaluations that measure the impact of protected area managemen...

Electronic health records (EHRs) were implemented to improve quality of care and patient outcomes. This study assessed the relationship between EHR-adoption and patient outcomes.We performed an observational study using State Inpatient Databases linked to American Hospital Association survey, 2011. Surgical and medical patients from 6 large, diverse states were included. We performed univariate...

Optimisation of radiation protection in fluoroscopy is important since the procedure could lead to relatively high absorbed doses both in patients and personnel resulting in acute radiation injury. Optimisation procedures include adjustment of the fluoroscopy equipment such as exposure factors as well as proper use of automatic brightness control and pulsed fluoroscopy. It is also important to ...

The success of Drosophila melanogaster as a model organism is largely due to the power of forward genetic screens to identify the genes that are involved in a biological process. Traditional screens, such as the Nobel-prize-winning screen for embryonic-patterning mutants, can only identify the earliest phenotype of a mutation. This review describes the ingenious approaches that have been devise...

Target based chemical screens are a mainstay of modern drug discovery, but the effectiveness of this reductionist approach is being questioned in light of declines in pharmaceutical R & D efficiency. In recent years, phenotypic screens have gained increasing acceptance as a complementary/alternative approach to early drug discovery. We discuss the various model organisms used in phenotypic scre...

! • m m • š›  œ ¡ €• ˆ œ  ¢‰2 £ ) € ™ ˆ touch|  |  ] m )Š+ n )š› m • m ¤ € ¥‰™ s   ¦‰§ € ̈©z{ { | ¦ { ‰a m  « 9 € ¬™­ ® ̄ °t± 2 ® ̄|® ́3Xμ ¶ ·) ̧ 1m°t¶o·) ̄|»1⁄21⁄43⁄4® ¿ À » ̄ÂÁ ED-projector

Visual inspection of cells is a fundamental tool fordiscovery in biological science. Modern robotic microscopes areable to capture thousands of images from massively parallelexperiments such as RNA interference (RNAi) or small-moleculescreens. Such screens also benefit from lab automation, makinglarge screens, e.g., genome-scale knockdown experiments, morefeasible and co...

We consider the propagation of piston mode in an acoustic waveguide obstructed by two screens with small holes. In general, due to features geometry, almost no energy incident wave is transmitted through structure. The goal this article show that tuning carefully distance between screens, which form a resonator, one can get complete transmission. obtain explicit criterion, not so obvious intuit...

The use of antimicrobial compounds in textiles has grown dramatically over the last decades. The potential application field is wide. It ranges from industrial textiles exposed to weather such as awnings, screens and tents; upholstery used in large public areas such as hospitals, hotels and stations; fabrics for transports; protective clothing and personal protective equipment; bed sheets and b...

It is recognized that high-throughput enzyme inhibition screens often return nonspecific inhibitors as "hits". Recently, high-throughput screens for enzyme activators have led to the identification of several compounds with novel and potent biological activity. Here, we show that enzyme activation screens can also uncover compounds that activate multiple enzymes in a nonspecific fashion. Descri...