BACKGROUND Adenocarcinoma of the prostate can present as metastatic carcinoma with no known primary. Prostatic origin can be confirmed in most of these cases by immunohistochemistry for prostate-specific antigen (PSA) and prostate-specific acid phosphatase. In a small subset of high-grade prostate carcinomas, both markers are negative and therefore are not helpful for confirming prostatic origi...

prostatic intra-epithelial neoplasia (pin) is considered a precursor of invasive carcinoma, characterized by proliferation and anaplasia of cells lining prostatic ducts and acini. in this study, we applied the pin grading system on one-hundred cases of prostatic carcinoma and one-hundred cases of benign prostatic hyperplasia, then compared the results. 74% of prostatic carcinoma and 51 % of pro...

BACKGROUND Small cell carcinoma of the prostate is an uncommon neoplasm, the origin of which has been controversial. To address this, we performed transcriptome profiling and TP53 sequencing of concurrent small cell and prostatic adenocarcinoma to determine the relationship between these entities. METHODS We identified an unusual case of primary prostate cancer that contained adjacent acinar ...

INTRODUCTION Based on the importance of the Gleason score on the behavior of prostate adenocarcinoma, this study attempts to predict the extension of prostate adenocarcinoma pre-operatively, as defined by the Gleason score on biopsy, in individuals who will undergo radical prostatectomy. MATERIALS AND METHODS We selected 899 individuals who underwent retropubic radical prostatectomy from 1988...

Despite recent advances in understanding the biological basis of prostate cancer, management of the disease, especially in the phase resistant to androgen ablation, remains a significant challenge. The long latency and high incidence of prostate carcinogenesis provides the opportunity to intervene with chemoprevention to prevent or eradicate prostate malignancies. In this study, we have used hu...

We recently reported that angiotensin II receptor blockers (ARBs) have chemopreventive and chemotherapeutic potential against prostate cancer via the reduction of androgen receptor (AR) expression. In this study, we investigated the effects of the angiotensin II receptor type 2 (AT2R) agonist Compound 21 (C21), which is expected to play similar roles to an ARB, on prostate carcinogenesis using ...

Small cell carcinoma(SCC) of prostate is a rarely seen agressive tumor. Generally, SCC of the prostate is symptomatic at diagnosis unlikely adenocarcinoma. In our study, 81 year-old male patient was admitted to our clinic with obstructive symptoms and dysuria. Transurethral resection of prostate was performed for the patient due to the obstructive symptoms. The pathology result was; small cell ...

Human angiogenin is progressively up-regulated in the prostate epithelial cells during the development of prostate cancer from prostate intraepithelial neoplasia (PIN) to invasive adenocarcinoma. Mouse angiogenin is the most up-regulated gene in AKT-induced PIN in prostate-restricted AKT transgenic mice. These results prompted us to study the role that angiogenin plays in prostate cancer. Here,...

Renal-type clear cell carcinoma (RTCCC) of the prostate is a rare form kidney cancer that infrequently reported in literature. Here we describe case an 81-year-old male patient with hard, immovable mass on his enlarged prostate, which was discovered through digital rectal examination. His prostate-specific antigen (PSA) level 23.01 ng/ml, and bone multi-slice computed tomography scans re...