background: misoprostol, a prostaglandin e1 analogue compared to prostaglandin e2, has the advantage of being inexpensive and stable at room temperature, with its proven efficacy and safety. however studies on the effect of ph on the efficacy of misoprostol have yielded conflicting results. thus its use in the induction of labour in patients with premature rupture of membrane requires further i...

Background. Administration of L-arginine improves nitric oxide (NO) formation and endothelium-dependent vasodilation in atherosclerotic patients. Objectives. We investigated in this double-blind, controlled study whether prolonged intermittent infusion therapy with L-arginine improves the clinical symptoms of patients with intermittent claudication, as compared with the endotheliumindependent v...

BACKGROUND Administration of L-arginine improves nitric oxide (NO) formation and endothelium-dependent vasodilation in atherosclerotic patients. OBJECTIVES We investigated in this double-blind, controlled study whether prolonged intermittent infusion therapy with L-arginine improves the clinical symptoms of patients with intermittent claudication, as compared with the endothelium-independent ...

Surgical Re-establishment of the Arterial Circulation in the Leg in Buerger's Disease : with Special Reference to the Efficacy of Prostaglandin E1 Used Concomitantly Author(s) OKAMOTO, YOSHIFUMI; NAKAYAMA, KENGO; WATANABE, HIROSHI; OSARAGI, MASATAKA Citation 日本外科宝函 (1981), 50(3): 501-508 Issue Date 1981-05-01 URL http://hdl.handle.net/2433/208532 Right Type Departmental Bulletin Paper Textversi...

Pigmented rabbits were given an intravitreous injection of 0.1 ml of various concentrations of test drug, and vitreous fluorophotometry was done 6 and 24 hr after injection. Dibutyryl cyclic adenosine monophosphate (AMP) and 8-bromo-cyclic AMP caused reversible intravitreous fluorescein leakage only at relatively high concentrations. Adrenergic agents that are effective stimulators of adenylate...

Exogenously added prostaglandins E1 and E2, but not F2alpha, inhibited the tumoricidal activity of interferon-activated macrophages of mice. A role for adenosine 3',5'-monophosphate (cyclic AMP) in modulating macrophage functional activity was suggested because prostaglandins of the E series increase intracellular concentrations of cyclic AMP in macrophages and because treatment of interferon-a...

5/3,7a-Dihydroxy-11-ketotetranor-prostanoic acid was the major metabolite excreted in the urine of guinea pigs injected with tritium-labeled prostaglandin E1, prostaglandin EP, 110~ ,15~-dihydroxy-9-ketoprost-5-enoic acid, lla-hydroxy-9,15-diketoprostanoic acid, and 11~hydroxy-9,15diketoprost-5-enoic acid. A method was developed for quantitative determination of 5p ,‘7cr-dihydroxy-l l -ketotetr...

Aortic infusion of prostaglandin E1 in a moribund infant resulted in marked clinical improvement. Appropriate studies were conducted and the diagnosis of hypoplastic left heart syndrome was made. Although the outcome was unaltered, the improved clinical condition allowed us to exclude potentially curable defects such as aortic coarctation and interruption.