Proprotein Convertase Subtilisin Kexin type 9 (PCSK9), comprises 12 exons, encoded for an enzyme which plays a critical role in the regulation of circulating low density lipoprotein. The gain-of-function (GOF) mutations aggravate degradation LDL receptors, resulting familial hypercholesterolemia (FH), while loss-of-function (LOF) lead to higher levels lower cholesterol, and preventing from card...