Cumulative relative survival curves for many cancers reach a plateau several years after diagnosis, indicating that the cancer survivor group has reached "statistical" cure. Parametric mixture cure model analysis on grouped relative survival curves provide an interesting way to determine the proportion of statistically cured cases and the mean survival time of the fatal cases in particular for ...

In smoking cessation clinical trials, subjects commonly experience a series of lapse and recovery episodes of varying lengths. Any quit episode may become permanent, in the sense that the subject stops smoking for good, and any lapse may also become permanent, in the sense that the subject abandons the quit attempt entirely. Individual quit patterns may reflect the effects of treatment and meas...

Senior managers in retail industry make important decisions upon assortment planning, product pricing, and product promotion. While product assortment is a strategic decision taken over a long-term planning period (Kök et al., 2006), the latter two are both strategic and tactical: they can be used in dayto-day marketing decisions to dynamically adjust to demand variations. Within the food retai...

Multi-scale model for response of the bi-material “thermostat,” consisting of a single unidirectional lamina of carbon/epoxy and an uncured layer of neat diglycidyl ether of bisphenol F (DGEBF) with curing agent, diethyltoluenediamine (DETDA), is developed in order to measure thermal strains during a prescribed, but arbitrary thermal history. Molecular modeling simulations provided the elastic ...

A simple model of adaptive control of promotional spending is analyzed. In the model, company sales (and therefore profits) are functions of promotional spending rate. Sales response to the promotion changes with time as a result of changes in a parameter of the sales response function. Information about sales response is collected in each time period by performing an experiment. On the basis o...

The HIV-1/AIDS pandemic continues to spread unabated worldwide, and no vaccine exists within our grasp. Effective antiretroviral therapy (ART) has been developed, but ART cannot clear the virus from the infected patient. A cure for HIV-1 is badly needed to stop both the spread of the virus in human populations and disease progression in infected individuals. A safe and effective cure strategy f...

The British Association for Sexual Health and HIV (BASHH) UK gonorrhoea guideline has been updated in 2011. It offers advice on diagnosis, treatment and health promotion for anogenital and pharyngeal gonorrhoea. Nucleic acid amplification tests (NAATs) are now being used more for diagnosis and are increasing detection rates in the pharynx and rectum. First line treatment using ceftriaxone with ...

O the years, researchers have found that promotion makes consumers switch brands and purchase earlier or more. However, it is unclear how promotion affects consumption, especially for product categories that are perceived to be versatile and substitutable. In this paper, we propose a dynamic structural model with endogenous consumption under promotion uncertainty to analyze the promotion effect...