background: studies have shown that mothers of premature newborns have lower physical and psychological quality of life compared to mothers of healthy neonates. therefore, applying a health promotion program for supporting them is necessary. aim: to determine the effectiveness of a health promotion program on the quality of the life of mothers of premature newborns. methods: in this quasi- expe...

The treatment of bladder cancer is usually performed by Bacillus Calmette-Guerin (BCG) instillation. BCG therapy is a common therapeutic method with fewer side effects compared with chemotherapy, radiotherapy, etc. BCG can also inhibit the progression and recurrence of bladder cancer by inducing apoptosis pathways, arrest cell cycle, autophagy, and neutrophil extracellular traps (NETs) formatio...

Vitamin D deficiency has a role in IBD pathogenesis, and although the mechanisms surrounding its remain unclear, it been suggested that autophagy dysregulation is involved. Here, we show increased ileal expression of autophagy-suppressing miR-142-3p mice were fed vitamin D-deficient diet “involved” colonic biopsies from pediatric patients with low D. serves as potential mechanism mediating redu...

programmed cell death, which can be classified into apoptosis, autophagy, and oncosis, based on the cellular signalling pathways involved in the process, plays a critical role in cellular house-keeping. aberrant cell death regulation leads to body malformations, as well as to numerous diseases. here, we describe the effects of cytototoxins isolated from marine organisms on the various programme...

Traumatic brain injury (TBI) is one of the leading causes of morbidity and mortality in young adults and children, and is a leading public health problem worldwide. In TBI, neurological impairment is caused by immediate brain tissue disruption (primary injury) and post‑injury cellular and molecular events (secondary injury) that exacerbate the primary neurological insult. However, the destructi...

Malignant cells often display defects in autophagy, an evolutionarily conserved pathway for degrading long-lived proteins and cytoplasmic organelles. However, as yet, there is no genetic evidence for a role of autophagy genes in tumor suppression. The beclin 1 autophagy gene is monoallelically deleted in 40-75% of cases of human sporadic breast, ovarian, and prostate cancer. Therefore, we used ...

Autophagy To overcome the autophagy compromised mechanism of protective cellular processes by “eating” damaged organelles or potentially toxic materials in tumor cells, Nan Li and co-workers show how tellurium double-headed nanobullets (TeDNBs)-HO is utilized to induce dysfunction. On one hand, TeDNBs-mediated endoplasmic reticulum stress could excessively autophagy; thus, resulting autophagoso...