نتایج جستجو برای: prolonged unconjugated hyperbilirubinemia
تعداد نتایج: 92836 فیلتر نتایج به سال:
Neonatal jaundice (NNJ) is the commonest problem in Hong Kong neonates.1 It is most likely to be unconjugated hyperbilirubinemia. Dramatic change was observed in last three decades with a sharp drop in incidence of kernicterus. This improvement was achieved through the concerted effort of the communi ty, neonato log ists, communi ty medical practitioners, health nurses. Significant effort was p...
Gilbert's syndrome is a benign condition characterized by asymptomatic sporadic episodes of jaundice, due to a mild unconjugated hyperbilirubinemia caused by a deficiency in bilirubin glucoronidation. Under certain physiologic or pathologic events bilirubin level rises but according to literature it does not reach out more than 3 mg/dl. We report 2 cases of Gilbert's syndrome, genetically teste...
Unconjugated hyperbilirubinemia in a blood donor: Chance finding due to unusual plasma discoloration
We appreciated the article by Gonnert and colleagues on hyperbilirubinemia from septic hepatocellular excretory dysfunction [1], a still improperly characterized issue in clinical settings. We address postoperative liver resection patients with prominently conjugated (~50 to 70 % conjugated) hyperbilirubinemia. Less relevant causes include transient insufficiency of remnant liver and prolonged ...
Abstract:Background : Hyperbilirubinemia is one of the most common cause of congenital sensory neuronal hearing loss. These patients are screened by auditory brainstem response (ABR) test at bilirubin levels higher than 1% of gestational weight. Aim: to determine whether hyperbilirubinemia less than 1% of gestational weight could induce hearing loss and abnormal auditory brainstem response (ABR...
In the 1940s and the 1950s, severe neonatal hyperbilirubinemia and kernicterus were most often encountered with hemolytic disease of newborn (HDN), which occurs most often as a result of the incompatibilities of the Rh and ABO blood groups. With the advent of prenatal testing, maternal Rh°(D) immunoglobulin, phototherapy, and exchange transfusion, the incidence of severe hyperbilirubinemia dras...
BACKGROUND The existing therapeutic methods for neonatal jaundice are costly, time-consuming and potentially risky. Zinc salts can reduce phototherapy duration by precipitating unconjugated bilirubin in the intestine (bilirubin and zinc can form a complex in physiologic pH); however, zinc toxicity is an issue that must be considered since theoretically bilirubin reduction by phototherapy may in...
BACKGROUND Mild but chronically elevated circulating unconjugated bilirubin is associated with reduced total and low-density lipoprotein cholesterol concentration, which is associated with reduced cardiovascular disease risk. We aimed to investigate whether unconjugated bilirubin influences macrophage cholesterol efflux, as a potential mechanism for the altered circulating lipoprotein concentra...
The syndrome of chronic unconj ugated hyperbilirubinemia without overt signs of hemolysis in adolescents and adults has been variously termed cholemie simple familiale (Gilbert's disease) (1), icterus intermittens juvenilis (2), hereditary nonhemolytic bilirubinemia (3), familial nonhemolytic jaundice (4), physiologic hyperbilirubinemia (5), and constitutional hepatic dysfunction (6). These ter...
Crigler-Najjar syndrome is a recessively inherited disorder characterized by severe unconjugated hyperbilirubinemia caused by a deficiency of uridine diphospho-glucuronosyl transferase 1A1. Current therapy relies on phototherapy to prevent kernicterus, but liver transplantation presently is the only permanent cure. Gene therapy is a potential alternative, and recent work has shown that helper-d...
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