نتایج جستجو برای: prolonged stress

تعداد نتایج: 521414  

2017
Abigail M Polter Kelsey Barcomb Rudy W Chen Paige M Dingess Nicholas M Graziane Travis E Brown Julie A Kauer

Stressful experiences potently activate kappa opioid receptors (κORs). κORs in the ventral tegmental area regulate multiple aspects of dopaminergic and non-dopaminergic cell function. Here we show that at GABAergic synapses on rat VTA dopamine neurons, a single exposure to a brief cold-water swim stress induces prolonged activation of κORs. This is mediated by activation of the receptor during ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2003
Klara R Birikh Ella H Sklan Shai Shoham Hermona Soreq

Behavioral reactions to stress are altered in numerous psychiatric and neurodegenerative syndromes, but the corresponding molecular processes and signal transduction pathways are yet unknown. Here, we report that, in mice, the stress-induced splice variant of acetylcholinesterase, AChE-R, interacts intraneuronally with the scaffold protein RACK1 and through it, with its target, protein kinase C...

2012
Andreas Maercker John Lalor

This review focuses on the similarities and differences between prolonged grief disorder (PGD) and post-traumatic stress disorder (PTSD). It highlights how a PTSD-related understanding aids the investigation and clinical management of PGD. Grief has long been understood as a natural response to bereavement, as serious psychological and physiological stress has been regarded as a potential outco...

Journal: :Proceedings. Biological sciences 2006
Lilach Hadany Tuvik Beker Ilan Eshel Marcus W Feldman

The reaction of the body to prolonged stress has many harmful effects. Classical theory assumes that stress responses have evolved due to their short-term selective advantages ('flight or fight'), and despite their adverse long-term effects. In contrast, we demonstrate that the adverse effects of stress responses may have a selective advantage. Using an analytical model we show that a gene that...

2017
Tadej Debevec Grégoire P. Millet Vincent Pialoux

Increased oxidative stress, defined as an imbalance between prooxidants and antioxidants, resulting in molecular damage and disruption of redox signaling, is associated with numerous pathophysiological processes and known to exacerbate chronic diseases. Prolonged systemic hypoxia, induced either by exposure to terrestrial altitude or a reduction in ambient O2 availability is known to elicit oxi...

آل بویه, رئوفه , حسینی سالکده, قاسم , حیدری, منظر , قناتی, فائزه , مرادی, فواد, کوباز, پریسا ,

The present study was undertaken in order to evaluate nativedesiccation tolerance and its mechanism in wheat seedlings of different genotypes. At the first step, drought stress was applied by using different concentrations of poly ethylene glycol (PEG) and mannitol. Since the fact that these compounds (even in high concentrations) were not able to produce sever water stress, the experiment was ...

Journal: :Journal of applied physiology 2004
Shelley Hurwitz Richard J Cohen Gordon H Williams

Exposure to prolonged bed rest is known to induce changes in the renin-angiotensin-aldosterone system (RAAS) by way of posture, sodium and potassium balance, and stress, which may have serious consequences for patients. We focused on the diurnal variation of the RAAS by investigating changes in the levels of plasma renin activity (PRA) and aldosterone; for comparison to markers of the intrinsic...

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