BACKGROUND We have previously reported that irradiation of mice in utero significantly increased the tumor incidence in the offspring of irradiated mothers. The joint effects of irradiation and cigarette smoking (CS) on tumor incidence and on the process of carcinogenesis were investigated. MATERIALS AND METHODS Pregnant C57Bl/6J female mice were irradiated with a single dose of gamma-ray (1 ...

Major basic protein (MBP), the core of the eosinophil granule, is a potent toxin for parasites and mammalian cells; it also causes histamine release from mast cells and basophils. Plasma levels of MBP are increased in all pregnant women, and MBP has been localized by immunofluorescence to placental X cells and placental-site giant cells. Analyses of plasma MBP levels during pregnancy showed a s...

BACKGROUND Intrahepatic cholestasis of pregnancy is associated with an increased risk of fetal death. The mechanism of death is unknown. CASES The first case involved a young primipara with pruritus and a bile acid concentration of 79 mumol/dL. While undergoing fetal heart rate monitoring, the fetus had a prolonged deceleration resulting in intrauterine death. The second case involved a young...

MOJ Womens Health 2017, 4(5): 00096 the umbilical cord briefness, uterine sudden decompression, deficiencies of folic acid, prolonged preterm membranes rupture, polyhydramnios and the former PA in the previous pregnancy [5]. Ananth et al. [6] conducted a meta-analysis recently and assessed the relationship between PA, prolonged rupture of the membranes and gestational hypertension. They found t...

In Indonesia, the MMR is still relatively high. general, main causes of death are complications pregnancy/delivery, namely bleeding 42%, eclampsia/preeclampsia 13%, abortion 11%, infection 10%, prolonged labor/labor stuck 9% and other 15%. Preeclampsia a problem that threatens pregnancy, especially in developing countries. Risk factors can increase cases preeclampsia include parity, extreme age...

The role of parity before and after N-methyl-N-nitrosourea (MNU) treatment in protection against mammary carcinogenesis was investigated. The effect of lactation on reduction in the incidence of mammary carcinoma was also examined. Parous rats were compared with respective age-matched virgins (AMVs). Pregnancy and lactation prior to MNU exposure significantly reduced both the incidence of mamma...

BACKGROUND Prolonged GnRH-a administration in IVF cycles may have some advantages related to the treatment outcomes. OBJECTIVE In this study, we aimed to analyse the effect of prolonged gonadotropin releasing hormone agonist (GnRH-a) administration on controlled ovarian hyperstimulation outcomes of in vitro fertilization (IVF) patients. MATERIALS AND METHODS In this retrospective study, 55 ...

During pregnancy, 5-14% of women are diagnosed with gestational diabetes mellitus (GDM) and the incidence has been increasing (Jovanovic & Pettitt, 2001; Paglia & Coustan, 2011). While insulin treatment is still the “gold standard” therapy for controlling maternal glycemia, the increasing use of oral anti-diabetic agents such as glyburide and metformin has begun to change standard care (Maymone...

Tissue hypoxia is the major stimulus of erythropoietin (EPO) synthesis in fetuses and adults. Since EPO does not cross the placenta and is not stored, fetal plasma and amniotic fluid levels indicate EPO synthesis and elimination. Acutely, the rate and magnitude of the increase in plasma EPO levels correlate with the intensity of hypoxia. Amniotic fluid EPO levels correlate with cord plasma leve...